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Essentialism in the DSM

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Essentialism in the DSM a look at schizophrenia and depression
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Look at schizophrenia and depression
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Crawford, Eric F. ( author )
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Denver, Colo.
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University of Colorado Denver
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Master's ( Master of social science)
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University of Colorado Denver
Degree Divisions:
College of Architecture and Planning, CU Denver
Degree Disciplines:
Social science

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Subjects / Keywords:
Depression, Mental ( lcsh )
Schizophrenia ( lcsh )
Depression, Mental ( fast )
Schizophrenia ( fast )
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bibliography ( marcgt )
theses ( marcgt )
non-fiction ( marcgt )

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The primary purpose of this thesis is to cast doubt on a global assumption of essentialism with regard to pathological categories in the DSM. To do this, it is first necessary to counter the universality claim that presents mental conditions as essentialist kinds. In this thesis, I am particularly interested in the two disorders of schizophrenia and depression. The structure of the argument is constructed in four parts. First, a theoretical presentation of essentialism will be developed and its application in the DSM will be described through the conditions, schizophrenia and depression. Second, a critique will be offered for the contemporary essentialist theories used to explain these conditions. Third, theoretical limitations of essentialism will be presented and a viable non-essentialist alternative offered through the explanatory strategy of population thinking. Finally, through this populationist approach, an alternative model will be postulated for describing the brain. The model will then be applied to our understandings of schizophrenia and depression and the vices or virtues of this alternative will be compared to current essentialist ideas held by the DSM.
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Includes bibliographical references.
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System requirements: Adobe Reader.
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by Eric F. Crawford.

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University of Colorado Denver
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Full Text
ESSENTIALISM IN THE DSM:
A LOOK AT SCHIZOPHRENIA AND DEPRESSION
By
ERIC F. CRAWFORD
B.A., West Chester University of Pennsylvania, 2004
A thesis submitted to the Faculty of the Graduate School of the University of Colorado in partial fulfillment of the requirements for the degree of Masters of Social Science Social Science Program
2017


This Thesis for the Masters of Social Science degree by Eric F. Crawford
Has been approved for the Social Sciences Program
By
Candice Shelby, Chair Omar Swartz Mark Bauer
Date: 04/28/2017
n


Crawford, Eric F. (M.SS, Master of Social Science)
Thesis Directed by Associate Professor Candice Shelby
ABSTRACT
The primary purpose of this thesis is to cast doubt on a global assumption of essentialism with regard to pathological categories in the DSM. To do this, it is first necessary to counter the universality claim that presents mental conditions as essentialist kinds. In this thesis, I am particularly interested in the two disorders of schizophrenia and depression. The structure of the argument is constructed in four parts. First, a theoretical presentation of essentialism will be developed and its application in the DSM will be described through the conditions, schizophrenia and depression. Second, a critique will be offered for the contemporary essentialist theories used to explain these conditions. Third, theoretical limitations of essentialism will be presented and a viable non-essentialist alternative offered through the explanatory strategy of population thinking. Finally, through this populationist approach, an alternative model will be postulated for describing the brain. The model will then be applied to our understandings of schizophrenia and depression and the vices or virtues of this alternative will be compared to current essentialist ideas held by the DSM.
The form and content of this abstract are approved. I recommend its publication.
Approved: Candice Shelby
iii


TABLE OF CONTENTS
CHAPTERS
I. INTRODUCTION...................................1
II. E S SENTIALISM AND THE DSM.....................9
A. INTRODUCTION TO ESSENTIALISM................9
B. THE MECHANISTIC STRATEGY FOR EXPLANATION....11
C. ESSENTIALISM IN THE DSM....................13
D. SUMMARY....................................18
III. CONTEMPORARY THEORIES PUT TO THE TEST.........20
A. TESTING THE CHEMICAL IMBALANCE THEORY.......20
B. EXPLORING CLAIMS OF GENETIC SUBSTRATES.....22
C. THE EFFICACY OF PRACTICE...................25
D. GLOBAL STUDIES OF SCHIZOPHRENIA AND DEPRESSION 30
IV. ESSENTIALISM VS POPULATION THINKING...........36
A. STATISTICAL MECHANICS AND THE LAW ABOUT
ERRORS.....................................37
B. ESSENTIALISM AND TAXONOMY..................38
C. HEALTH, ILLNESS, AND FITNESS...............40
D. POPULATION THINKING........................42
V. THE NON-ESSENTIALIST BRAIN....................46
A. UNDERSTANDING THE BRAIN....................47
B. A NON-ESSENTIALISM ALTERNATIVE.............50
IV


C. SHIZOPHRENIA, DEPRESSION, AND POPULATION
THINKING..................................53
D. SUMMARY..................................60
VI. SUMMARY AND CONCLUSION.....................62
\ II WORKS CITED................................66
VIII. REFERENCES.................................68
v


CHAPTER I
INTRODUCTION
The purpose of this thesis is to cast doubt on a global assumption of essentialism that underlies pathological categorization in the psychological document known as the Diagnostic and Statistical Manual of Mental Disorders (DSM). This pre-classificatory assumption presumes that all mental conditions are the result of essentialist causes and thus precludes any other possible approach to describing such phenomena. I argue that progress toward the understanding and treatment of certain mental illnesses has been stymied for this reason. In order to cast doubt on this global assumption, all that is needed is to undermine the universality claim in the DSM, which views mental disorders as essentialist kinds. To this end, I will focus on two mental conditions, schizophrenia and depression. The argument will be made as follows.
When discussing ideas of health, there is an assumption that healthy states are those where the operational processes of an individual are functioning normally. This implies that states of illness reflect some abnormality or dysfunction in these processes. Such assumptions then divide ideas of health and non-health between processes that are normal and those that are the result of a disturbance to this normal function. This view is essentialist. Essentialism is an explanatory strategy wherein types are described and categorized by means of identified mechanisms or properties. These properties are the constituent conditions that explain why a type or category is the way it is. This explanation of phenomena assumes that any deviation from the type reflects some interference or malfunction of the underlying causal mechanisms.
1


Within the fields of clinical psychology and psychiatry, the DSM is the cardinal
document by which mental illnesses (states of mental non-health) are identified and
categorized. The DSM defines a mental disorder as:
a syndrome characterized by a clinically significant disturbance in an individuals cognition, emotional regulation, or behavior that reflects a dysfunction in the psychological, biological, or developmental processes underlying mental function. Mental disorders are usually associated with significant distress or disability in social, occupational, or other activities.1
The definition of mental disorders is therefore essentialist as these mental syndromes are identified by clusters of diagnostic concepts (symptoms), which reflect a dysfunction within the underlying mechanistic processes that constitute mental function.
Furthermore, this definition reveals a global assumption of this essentialist strategy presuming that all psychological pathologies can be explained uniformly as deficiencies or dysfunctions of underlying mechanisms.
In making the point against the global assumption of essentialism in mental disorders, I focus on the two conditions of schizophrenia and depression. It would be fair to expect that if our understanding of these psychiatric illnesses is correct, resulting treatments will be effective and therefore appropriate. If recovery rates are low on the other hand, confidence in global descriptions of unified mechanisms for pathological conditions would be called into question. Even if therapeutic treatments were to prove ineffective, however, that would not necessarily mean that the essentialist explanatory strategy has failed. There are three possibilities that could account for such an issue.
One possibility would be that the correct essentialist mechanism has simply not, as yet, been identified and further investigation is required. A second possibility is that the issue results from a conflation of multiple conditions each with a possible diversity of
2


mechanisms. Lastly, the most radical possibility and what I will argue in this thesis, is that the conditions of schizophrenia and depression, as described by the DSM, do not exist.
I will argue that the first two possibilities can be set aside due to problems that arise from the global assumption of essentialism. The central issue with the essentialist strategy is the degree to which it is able to account for variance. The variance among symptom presentations and a diversity of response to treatment observed in clinical practice are viewed, in this light, as anomalies. I argue, however, that this should be expected when applying essentialist assumptions to something like the categorization of mental disorders. As such, a non-essentialist alternative may prove to be more advantageous in accounting for this diversity and would therefore provide a better means of explaining the phenomena experienced by those diagnosed with these conditions. I propose that one such alternative can be found in population thinking. As a non-essentialist explanatory strategy, population thinking focuses on the diversity of features as they are distributed across a population rather than seeking similarity among category members. In this context, similarity is the feature that requires explaining.2
Through approaches used in population thinking, models can first be generated that view the brain, rather than a mechanistic organ, as an adaptive and interrelational population of neural signaling connections. To view the structure of the brain as a populational system, could provide not only a better way of understanding anomalies in conditions such as schizophrenia and depression, but the human psychological system, as a whole. Through this foundational understanding of the brain, the populationist strategy
3


can then be applied separately to the phenomena of schizophrenia and depression on the macro level of larger human populations.
If these alternatives prove viable and more parsimonious in accounting for the phenomena associated with these conditions, then it is possible that there would be no need to define them on an essentialist basis. Absolute confidence in the essentialist kinds of schizophrenia and depression as described by the DSM would then be called into question. As such, doubt would be cast on this global assumption of essentialism as it pertains to the categorization of mental conditions in general. This is not to say that the DSM would need to be discarded or that essentialist explanations do not attain for some conditions, merely that it would no longer be possible to universally assume essentialist claims of pathology. Empirical justification would therefore be needed for each category prior to further engagement with the DSM.
As stated, this thesis will focus on the conditions of schizophrenia and depression. It is therefore important to provide a foundational understanding of these conditions. Schizophrenia is described in the DSM-IV-TR, as a constellation of symptoms involving a range of cognitive and emotional problems that may impair an individuals occupational or social functioning. The description furthermore conceptualizes the symptoms of schizophrenia through positive and negative categories. Either or both of which can be present for an individual. Positive symptoms of schizophrenia, such as delusions and hallucinations, reflect an excess or distortion of normal function, while negative symptoms, such as restrictions in emotional expression (flattened affect) or motor function (catatonia), appear to reflect a diminution or loss of normal function. Diagnosis of this condition is clinically warranted, according to the DSM, only if two out
4


of five characteristic symptoms (i.e. delusions, hallucinations, etc.) are present for at least one month, while other symptoms must be present for 6 months.3
Schizophrenia is classified as a psychotic disorder, as the dysfunction deals with a loss of touch with reality. Depression, on the other hand, is a disorder of a different kind. The diagnosis of depression is classed as a mood disorder, which is to say, a disorder that has a disturbance of the mood [or emotion] as its predominant feature. These conditions are described as expressing or presenting in one of two ways: either episodically (distress that occurs for a short period and then resolves) or as a chronic disorder (consistent return of episodes of distress). Major Depressive Disorder, then, is characterized as the experience of multiple episodes (periods of at least two weeks) where any five of the nine characteristic symptoms of depression (i.e. depressed mood or irritability, hopelessness, fatigue, change in appetite, change in sleep, loss of interest/motivation, difficulty concentrating, guilt/worthlessness, and thoughts of suicide) are present.4
It should be noted that the list of symptoms for both of these conditions are not the conditions themselves. Six months of feeling sad, fatigued, etc. are not in and of themselves Major Depressive Disorder. Equally, hearing voices is not schizophrenia. These symptoms are simply identificatory factors that suggest a pathological state is present. As previously stated, this conditioned state is said to be the dysfunction of underlying structural mechanisms. In this way, it is clear that the DSM is married to an essentialist view when it comes to categorizing taxonomies of mental illness. This seems sensible as this strategy is certainly viable in many other scientific endeavors, as
5


mechanistic approaches are in many cases central to the scientific practice of investigating phenomena and studying processes and sequences of events.5
In regard to the categorization of mental illness, malformed neurology, altered genetics, and imbalanced biochemistry have all been cited as the malfunctioning or structured mechanisms that are linked to the emergence of these pathological mental states. In this paradigm, once these parts of the brain become pathological, the disordered psychology and behaviors will continue to reflect such deviation in chronic fashion in the absence of therapeutic intervention. While this represents a reasonable methodology as applied to clinical practice, I argue that it is just these assumptions that pose the greatest threat to understanding these mental illnesses.
To recapitulate, the central argument of this thesis is as follows: There is an assumption that states of health are those where the processes of an individual are functioning normally. States of illness are reflective of some dysfunction of these processes that disrupt this normal function. This view is essentialist.
The Diagnostic and Statistical Manual of Mental Disorders (DSM) provides a foundational paradigm by which pathological mental states can be diagnosed, described, and understood. Mental disorders are defined by the DSM as syndromes that reflect a dysfunction in the processes that underlie mental function. This definition reveals a view of essentialism that specifies how all mental disorders (i.e., schizophrenia and depression) are to be categorized and understood. The pre-classificatory assumption that is exposed by this definition is that mental disorders can only be understood as the result of some dysfunction among the mechanisms that constitute mental function.
6


Clinical therapeutic approaches for these conditions reflect and are derived from this paradigm. If therapeutic models are not effective in the treatment of schizophrenia and depression, then the accuracy and appropriateness of these diagnostic definitions becomes suspect. We are then left with three possibilities to account for this. First, the correct mechanism has yet to be identified and further investigation is required. Second, multiple conditions have been conflated into one, each with a possible multiplicity of causal mechanisms. And lastly, the conditions of schizophrenia and depression do not exist in the way that they are described in the DSM. If the last possibility is true, then a non-essentialist alternative must be proposed.
Through the approach of population thinking, models can be generated that may provide a better way of understanding the human psychological system, as well as, anomalies in conditions such as schizophrenia and depression. If such models prove to be viable alternatives, then it would be possible that schizophrenia and depression would not require essentialist terms to define them. Without the necessity of an essentialist definition, the credibility of the descriptions provided by the DSM for these conditions would be undermined. Doubt would then be cast on the acceptance of essentialism in the DSM as a global assumption. Empirical justification would then be needed for any essentialist claims of pathology made in the DSM.
The case for this argument will be built in four sections. Chapter II will be an exploration of essentialism and the mechanistic approach of explanation. Beginning with the Natural State Model of Aristotle, I will develop a more extensive conceptual description of essentialism. Following this, I will apply the essentialist explanatory strategy to the DSM, describing what essentialism looks like as an explanatory strategy
7


with regard to the mental conditions schizophrenia and depression. In Chapter III, our discussion will turn to an analysis and critique of the contemporary mechanistic theories offered for the essentialist understanding of schizophrenia and depression. Through current research and statistical studies, questions will be raised about the globalized assumption of this essentialist approach. In Chapter IV, the limitations that an essentialist strategy has posed for other sciences such as biology and statistical mechanics will be presented. Finally, an alternate, non-essentialist approach will be offered through the strategy of population thinking on the merits of certain advantages that this approach has offered for fields such as evolutionary biology. With the theoretical foundation for a non-essentialist alternative described, Chapter V will describe, first, a non-essentialist approach to understanding the brain. A model will be proposed that describes the systems of the brain as interrelational and adaptive populations of neural signaling connections. The virtues of this approach will then be explored with regard to understanding the mental conditions of schizophrenia and depression. On the basis of this foundation, a further populationist model will be presented for investigating the phenomena of schizophrenia and depression on the macroscopic level of the larger human population. With the alternative presented, a case will be made for how such an alternative could undermine confidence in the traditional understanding of these conditions and doubt cast on the global assumption of essentialism with regard to pathological categories in the DSM.
8


CHAPTER II
ESSENTIALISM AND THE DSM
As previously stated, the definition offered by the DSM for mental disorders reveals a global assumption that pathological conditions result from a dysfunction of some underlying structural mechanism. While it may be appropriate locally on a case by case basis, I suggest that this assumption of essentialism may prove problematic when applied universally. Before pursuing that argument further, however, it would be beneficial to develop a deeper understanding of the essentialist explanatory strategy. To do this, I will first provide a definition of essentialism and describe the origins of the strategy through Aristotles Natural State Model. Examples of where the essentialist strategy has been effective in scientific inquiry will be offered and the mechanistic model described. I will then present what the essentialist approach looks like in the DSM along with its influence on the development of contemporary theories used to account for the mental conditions of schizophrenia and depression.
Introduction to Essentialism
Essentialism is an explanatory strategy wherein types are described and categorized by means of identified mechanisms or properties, called essences. The identity of a category is constituted by this set of necessary and sufficient properties or conditions which explain why members of the category are the way they are. Such conditions are intended to reflect underlying causal, structural mechanisms that explain the similarities observed among category members. These necessary and sufficient properties are category identifiers that provide the conditions for membership to the category. The point of this category individuation is the explanatory value when seeking
9


to explain observed similarity. Variation, in this context, reflects some interference or malfunctioning of the underlying structural mechanisms that constitute this category identity.1
Chemistry describes the essence of water, for instance, as the composition of two hydrogen atoms and one oxygen atom. The explanatory value of this description is that we are able to explain how water molecules behave due to the covalent bond formed by the combination of these essential parts. It is this understanding that explains why ice becomes lighter than water as the liquid changes to a solid state. In biology, the essentialist requires that a species be categorized in terms of the characteristics of the organisms that belong to it. Whether applied to categories of atomic elements or species of organisms, these constituent definitions can be understood as the whole being defined in terms of its parts. In this way, such definitions can be seen as reductionist as higher level concepts are only legitimate if they can be defined in terms of their lower levels.2
Essentialism follows largely from what is called the Natural State Model (NSM), first proposed by Aristotle in his explorations into the studies of biology and physics. Through the NSM, Aristotle offers a method by which one can identify types and account for diversity among all natural objects. According to this thinking, there is a divide between the natural state of an object and unnatural states. The difference between these states is the result of some interfering force having been enacted upon the object. Similar to our current ideas of health and non-health, Aristotle specifies that variation within species in nature is thus to be accounted for as a deviation from what is natural.3
10


For biology, Aristotle suggests that in any natural state, which is one that lacks interfering forces, like will produce like. Variation, however, occurs regularly in nature within and between species. According to Aristotle, such variance can only occur naturally through spontaneous generation, a process which is governed by its own laws. The reason why offspring are not exact copies of their parents is due to a deflection from the natural pattern caused by some form of interference during reproduction. These deflections can result in either the alterations of accidental characteristics such as size or hair color which differ from the species-norm, or greater deficiencies in the offspring that are the result of imperfect ontogenic processes.4 The Mechanistic Strategy of Explanation
The application of essentialism as an explanatory strategy most commonly follows a mechanistic model. Central to scientific practice, mechanistic models investigate the source of phenomena or study the sequence or process of salient events.5 As previously stated, we know this strategy to be essentialist as it seeks to breakdown things and phenomena to identify causal components that explain why said things and phenomena are the way that they are. The explanatory value of the mechanistic approach is the ability to not only understand how singular events occur, but to create models by which future phenomena can be understood and predicted wherever certain conditions are present.
We can understand the mechanistic approach as follows. There is a thing, be it an organism, phenomenon, etc. There are mechanisms that compose the thing, essences for instance, that explain why the thing is the way that it is. To understand the thing, essential mechanisms must first be sufficiently isolated from other variables. Once
11


isolated, the mechanism is sought and identified that can be said to cause an effect, the outcome is the thing in question. This is to say that the thing is determined to be what it is as a direct and necessary result of the essential mechanism. The explanatory value of this is that if the isolated mechanism has been sufficiently identified, one can reasonably generalize and predict ceteris paribus, the determined outcome wheresoever that mechanism is present and functioning.
An example of this is where scientists and philosophers have applied this approach in biology to isolate the basic mechanisms that explain the physiological operations of living beings. In turn, these inquiries into the activities and interactions of biological components have led to the development of cell theory. By labeling the cell as the fundamental mechanism of organization and function, cell theory treats the cell as the locus of all major organismic processes, including metabolism, development, reproduction, and heredity.6 Equally, this strategy has been effective in describing the development of various organisms, and in particular the general similarity of individuals within a species. It is due to the genome sequence, for instance, that some organisms begin as eggs and follow through stages of development from larva (caterpillar) to pupa (cocoon) and eventually the mature imago of an adult butterfly. Although individual butterflies may be different in appearance due to a range of factors, it is due to mechanisms of genome evolution that the butterfly will never start out as a caterpillar and transform into a fruit fly although the ontogenic processes of both are quite similar. The genome sequence of each species is the mechanism that determines not only the process by which individual organisms develop, but to a large degree, what the ultimate result of that process will be.
12


Another example of the appropriate application of the essentialist strategy in scientific inquiry can be seen in many aspects of medicine. With regard to anatomy, the essentialist strategy has helped not only identify the organs of the body, but to break them down further to discover the mechanisms that contribute to their proper operating function. As a result, we know that hearts are muscles that consist of four-valved chambers and circulate blood through the body. Lungs are pairs of air filled organs that are composed of tubular branches, called bronchi, which in turn branch out further into bronchioles. The function of this organ is to oxygenate the blood and remove carbon dioxide waste. When these organs fail to perform their function, we are able to investigate as to where there are deviations from the proper operating conditions.
More pertinent to the methods outlined in the DSM is the model used in medicine to identify infectious disease. A patient presents with certain symptoms that suggest the existence of an underlying condition, in this case an external pathogen. Tests can then be performed to confirm that such a pathogen, be it a virus, bacteria, etc. is present.
Through research and empirical support, treatments are devised to combat these pathogens and return the patient to a state of health. It is just this paradigm that was utilized by Eli Robin and Samuel Guze for the DSM-III where mental disorders were first categorized as discrete and discontinuous conditions.7 Essentialism in the DSM
Having seen a few cases where this strategy has been fruitful, it would help to understand how the view of essentialism is applied to the classification of mental disorders in the DSM. As stated, the functional language found in the definition of mental disorders is essentialist and reveals a pre-classificatory assumption that precludes
13


the possibility of accounting for these conditions in any other way. The diagnosis of a mental illness, such as schizophrenia or depression, is recognized in a patient if a threshold of symptoms is present over a prescribed period of time. These identificatory thresholds, which are determined by consensus through clinical case studies, are said to be caused by the dysfunction of some structural mechanism. The respective causal mechanisms are then sought to inform the development of therapeutic treatments.
The endeavor to isolate mechanisms that cause mental illness can be traced at least to the 19th century. This search revolves almost entirely around attempts to isolate deviated biological substrates to explain why and how pathological states (i.e., schizophrenia and depression) emerge. With the advent of neuroscience in the 1860s, the claim was that mental illness occurred as a result of stressed nerves. Before that, the explanation offered by medicine was brain lesions. Today, theories are offered ranging from imbalances among neurochemicals, malformations in neurons, genetic anomalies, and developmental deficiencies resulting from obstetrical trauma. This mechanistic approach is evidenced not only in the theories offered but also in the methods for exploration. From the dissection of brains at autopsy, testing levels of neurochemicals in spinal fluid, to comparing rates of mental illness among twins, each seeks to isolate a biological mechanism from other potential variables.
The first of the contemporary theories offered to explain schizophrenia and depression is the chemical imbalance theory. Following successful advancements in medicine to identify medications that could be utilized to combat infectious diseases, an idea emerged that perhaps similar success could be achieved in the treatment of mental
14


illness. By the 1970s, the predominant view was that major psychiatric illness rested on a substrate of disordered brain chemistry.8
The first drug that heralded what came to be known as the pharmacological revolution in psychology was Chlorpromazine. Originally used as a surgical anesthetic, Chlorpromazine appeared to disconnect the regions of the brain that control motor function and the capacity for general emotional response.9 Thorazine, as it was renamed, was classified as a neuroleptic for its ability to take hold of the nervous system. When tested on patients with schizophrenia, its effects were reported as profound. Patients would sit up and talk sense, according to a series of articles in the U.S. News and World Report, patients who were formerly untreatable, within a matter of weeks and months, became sane, rational beings.10 Thorazine brought freedom from confusion and peace of mind to the most unreachable patients.11 Touted as a miracle pill, Thorazine caused a remission of hallucinations, delusions, and thought disorders associated with schizophrenia; it was later re-named as an antipsychotic.12 Thorazine became psychiatrys first magic bullet.
Imipramine was one of the next to be widely used. First tried on patients with schizophrenia, its effect made them more energetic and often prone to agitation. For this reason, it was then tested on those diagnosed with depression, with dramatic results. Roland Kuhn testified that patients grew more lively... the yammering and crying came to an end... some were ready to jump out of their beds in the morning.13
As a result of these pharmaceutical endeavors, the two primary players that took center stage for this neurological endeavor were the neurotransmitters dopamine and serotonin. The dopamine system plays a role in numerous processes in the brain and
15


body. Dopaminergic neurons are responsible for controlling movement, regulating emotions, and activating processes involved in the higher executive functions associated with personhood.14 Dopamine was first suspected to have some connection with schizophrenia when it was observed that Thorazine seemed to alter dopamine levels in mice when administered. The thought was that since it seemed to have such a profound impact on schizophrenia, the disease might be caused by some issue with the dopaminergic system. The suspicion was strengthened when schizophrenic symptoms worsened following the administration of amphetamines, which potentiate the actions of dopamine in the brain.15
With regard to depression, the National Institute for Health took up research in the mid-50s, testing the belief that serotonin, or 5-HT, could be responsible for some psychiatric illness. In the body, serotonin is involved in respiratory, cardiac, and digestive processes. Moving into all parts of the brain, serotonergic neurons are associated with sensations of satiation, calmness, energy levels, and wellbeing. When imipramine was administered to patients in England during 1960s, it was noted that their blood levels of serotonin seemed to drop off. This observation led to the discovery of the reuptake mechanism in neurons. Antidepressant drugs cause serotonin to be sequestered in the area between the neurons, called the synapse. Tricyclic antidepressants such as Imipramine accomplish this particularly by preventing serotonin from being reabsorbed by the initiating neuron. The less reuptake, the more serotonin that is available for the connecting neuron, and the more it is able to work against depression, or so the theory goes. Alternatively, antipsychotics attach to the dopamine receptors of the connecting neuron, preventing them from receiving.16 The claim made
16


here is that mental illness is the result of either the overabundance or deficiency of certain neurotransmitters in the brain.17
While research continued into the chemical-imbalance theory, advancements in the second half of the 20th century provided another vehicle for exploring biological disorders through the field of genetics. Quantitative data was needed to rule out environmental effects when comparing patients with schizophrenia and depression to controls. Twin studies were introduced, the logic behind which is that identical, or monozygotic, twins develop with a single fertilized ovum and have a common set of genes... making them more alike, in all ways in which genes play a part, then binovular (dizygotic) twins.18 The assumption was that any differences between the twins would be purely due to environmental influence. What was revealed was a compelling connection to heredity as least for schizophrenia as the studies showed a concordance rate between monozygotic twins at around 50%, as opposed to a 15% concordance with dizygotic twins.19
Seymour Kety, best known for the adoption studies into mental illness, took records from the first half of the 20th century for all of Denmark, noting the number of adopted children that were later admitted for a psychiatric illness. With a particular focus on schizophrenia, he was able to compile enough information by 1992 to claim that almost half of the adoptees that later presented with schizophrenic symptoms had some form of the disease in their biological families, verses practically none for the control group. While not conclusive, the results were certainly compelling in suggesting a non-environmental source for schizophrenia: The genetic news implied that these illnesses must have a significant brain substrate, however much environmental circumstances
17


might trigger them.20 In 1995, the genes alleged to cause schizophrenia were tentatively placed around Chromosome 6, whereas Chromosomes 18 and 21 seemed to be correlated with manic depressive illness.21
Eventually, however, studies in neuropathology discovered that genes did not need to be the cause of such conditions as schizophrenia. Non-genetic anomalies in the womb as well as obstetrical trauma are now cited as possible sources of damage to the developing brain, making the individual vulnerable to mental illness later in life. During the autopsy of numerous adult schizophrenics, a proliferation of glial cells, called gliosis, which is common with those who have experienced trauma to the CNS, have been found in the specific regions of the brain that indicate possible fetal maldevelopment.22 Summary
To recap, the essentialist strategy for explanation is a method of individuating categories by means of necessary and sufficient conditions. These conditions are said to reflect underlying causal structural mechanisms that explain observed similarities among category members. Variation among members is thus accounted for as a deviation from the type, reflecting some interference or malfunctioning of these causal mechanisms.
This strategy has proven fruitful in many science, such as chemistry and biology.
Most notable for this thesis is the impact that essentialism has had on the study of human anatomy and infectious illness in western medicine. Such essentialist concepts of health and non-health were highly influential in the development of the DSM. The globalized essentialist perspective is revealed in the DSM through the definition of mental disorders which states that such conditions reflect a dysfunction of the underlying mechanistic processes that constitute mental function. This pre-classificatory assumption
18


precludes any other possibility for accounting for mental conditions. The three major essentialist theories that have been offered for the conditions of schizophrenia and depression include the theory of imbalanced neurochemicals, deviations due to genetic anomalies, and developmental deficiencies that result from obstetric trauma. With the understanding of these ideas developed, the tenability of these theories can now be tested.
19


CHAPTER III
CONTEMPORARY THEORIES PUT TO THE TEST
So far, a theoretical understanding of the essentialist/mechanistic strategies for explanation has been developed along with a description of how the essentialist approach informs our contemporary understandings of schizophrenia and depression provided. It is necessary now to determine whether the contemporary biological and genetic theories prove empirically tenable. First, we will explore studies that span over 50 years to test the essentialist-oriented claims that depression and schizophrenia arise from deviations in various biological or genetic mechanisms. Second, clinical studies into contemporary therapeutic practice will reveal the influence that this essentialist view has had on the treatment of mental illness through the observation of recovery outcomes and the effectiveness of said therapeutic regimens. Following that, the chronic projections detailed in the DSM for schizophrenia and depression will be tested against long term research studies performed by the WHO that have tested global rates of incidence, typical course of illness, and recovery rates since the 1960s.
Testing the chemical imbalance theory
We begin with the chemical imbalance theory for schizophrenia and depression. As our understanding of neurobiology has expanded, it was discovered that the neurotransmitters, dopamine and serotonin, are metabolized as they pass through their respective systems in the brain. The resulting metabolites are then released into the cerebrospinal fluid, providing neuroscientists with a method by which to test the levels of these neurochemicals. Serotonin, it was determined, is metabolized into 5-hydroxyindole acetic acid (5-HIAA) while dopamine is processed into homovanillic acid, also known as
20


HVA.1 Levels of each of these chemicals can be reliably tracked and measured. If depression can be linked to low levels of serotonin in the brain, then the cerebrospinal fluid should reflect this with low levels of 5-HIAA. Alternatively, the chemical-imbalance theory for schizophrenia would argue that high levels of HVA should indicate an overabundance of dopamine. A simple method for testing the neurochemical theory of brain dysfunction seemed to be realized.
In 1975, Marie Asberg-Stockholm released the results of a six year study testing the relationship of serotonin levels with depression. One group of individuals diagnosed with depression was tested alongside a control group called normal. Of the normal group, 25% were found to have low levels of 5-HIAA. 50% had levels in the middle of the range and 25% had levels that were deemed high. Results for the depressed group were nearly identical to the control, revealing serotonin levels to be an unreliable indicator of a neurochemical cause of depression. This study was replicated and results were confirmed by a second study run by the National Institute for Mental Health (NIMH) in 1984, which concluded that levels of cerebrospinal 5-HIAA varied in persons across both groups of depressed and non-depressed individuals. Of particular note is that these results were shown to also be true for those undergoing pharmaceutical treatment with antidepressants.2 These studies, among others, seemed to put the analysis of depression in terms of serotonin levels to rest for a time.
Following the release of Prozac by the pharmaceutical company Eli Lilly in 1988, however, there was a resurgence of the chemical imbalance theory of depression. Eli Lilly touted Prozac as a chemical cure for the alleged imbalances responsible for depression. Studies were conducted by Stanford psychiatrist David Bums in response to
21


these claims, producing the same results as before. In 2003, after working for years studying brain serotonin metabolism, Burns concluded that he never saw convincing evidence that any psychiatric disorder including depression results from a deficiency of brain serotonin.3
Similarly, dopamine has long been the neurotransmitter associated with the disorder of schizophrenia. The theory purports that imbalances contributing to schizophrenia specifically involve the Di and D2 dopamine receptors. Since cerebrospinal HVA levels proved to be normal in unmedicated schizophrenics as compared to control groups, the theory arose that perhaps patients had an overabundance of those dopamine receptors. Autopsy and brain scan studies through the 1980s indeed revealed a proliferation of D2 receptors in patients diagnosed with schizophrenia. The problem was, however, that this was only the case in the brains of those treated with neuroleptics. Unmedicated individuals with schizophrenia showed no reported differences with regard to abnormal D2 receptors when compared with normal controls.4 Former director of NIMH Steve Hyman explains that the reason for this is that all psychotropic drugs, in fact, perturb the normal function of neurotransmitters. Confirmed by over 30 years of research, Hyman argues that not only can the chemical imbalance theory be judged false; it has moreover become clear that it is only after exposure to medications that a chemical imbalance ever comes to exist.
Exploring claims of Genetic Substrates
The previously mentioned adoption and twin studies of the 20th century, while not conclusive, certainly showed a strong correlation between heritability and schizophrenia. To review, studies revealed a high concordance rate for schizophrenia among
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monozygotic twins where 100% of the genetic material is shared as compared to dizygotic twins that share only 50% like typical siblings. Of these groups, the risk for monozygotic twins ranged from 40-50%, where as the risk that both dizygotic twins would develop the condition was only 10-15%.5 Equally, the risk appears to be much higher for children of parents with schizophrenia that were adopted by non-schizophrenic parents than for children where the case is reversed. By 2008, a meta-analysis had been compiled by Tandon et al. of much of the research that followed those earlier studies into the genetic and developmental elements of the condition. In the article Schizophrenia, Just the Facts What we know in 2008, the research into contributing factors for schizophrenia was reviewed. However, the conclusions of decades worth of exploration into genetic or ontogenic risk factors were not particularly noteworthy.
Following advancements in the mapping of the human genome, approximately 4000 genes were identified that could indicate a susceptibility for schizophrenia.6 Despite the identification of numerous genetic markers, many of which seemed promising in the search for so called risk genes, consistent replication of these markers remains elusive. As such, the mechanism(s) for the aforementioned heritability of this condition remain equally obscure.7 Yet it is entirely possible,, Tandon acknowledges, that with more time, scientists may be able to identify which genetic features might be liable for the emergence of schizophrenia in an individual. The ability to produce more consistent findings through research into other complex genetic diseases, however may suggest a need to look at the problem in different ways. The most notable of these are whether our current genetic framework is most suitable for future inquiry, and how appropriate schizophrenia is as a phenotype to warrant such genetic study.8
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With the challenges of consistently recognizing variations in DNA sequencing, one alternative that has been offered is that the genetic origins of schizophrenia can be seen as heritable changes to gene expression. While such epigenetic approaches have been fruitful in the study of other neurodevelopmental disorders, according to Tandon, the precise roll in the etiology of such complex conditions as schizophrenia remains to be clarified.9 Tandon et al then argue that the ability to pinpoint a genetic basis for schizophrenia is further complicated by the numerous and often disparate phenotypic presentations or symptoms associated with the diagnosis. For this reason, Tandon suggests, that schizophrenia genes do not, perhaps, code for schizophrenia per se, but for some broader clinical construct, such as psychosis.10 Equally, another possibility to be considered is that there may not be just one schizophrenia, but rather it may be several different diseases with similar clinical presentations. If this is the case, Tandon argues that explanation would be required for the co-occurrence of these multiple dimensions, each with their own etiologies, would have to be explained.11
Outside of the genetic framework, a great many developmental and environmental theories have been suggested for explaining schizophrenias origins. These suggest associations between an increased risk for schizophrenia and occurrences ranging from such obstetrical issues as prenatal malnutrition to early childhood trauma to even cannabis use in adolescence. None of these suggested connections, however, provide definitive links to the eventual development of schizophrenia. Maternal influenza seems to be correlated at a higher incidence rate than other natal infections, but the precise reason for this is unknown. Obstetric complications are linked to a doubling of the risks of schizophrenia, which suggests that such issues lead to a sensitization of the individual
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to stress. The precise mechanism though is unclear, as is the manifestation of that sensitivity into schizophrenic symptoms.
Ultimately, the discrepancies in the findings, which are myriad, derail the investigation with no one genetic or environmental factor appearing to be necessary or sufficient for causing schizophrenia.12 Each attempt to isolate the causal factors of schizophrenia have been inconclusive as such identifiers have not been replicated on a consistent basis. And so, the assessment made by Tandon et al with regard to the genetic and developmental causes of schizophrenia is just the same as this thesis. With the inability to reliably pinpoint either biological or environmental causes for this condition we are left with one of three possibilities. First, as technology continues to advance we may find that we are better able to identify what genetic variations may result in schizophrenia.13 Second, that there are many schizophrenias, each with their own etio-pathogenic processes. And third, that the condition of schizophrenia in a genetic or developmental sense is not productive and such factors refer more appropriately to higher level constructs, such as psychosis.14 The Efficacy of Therapeutic Practice
To press the possibility that the essentialist view might represent a bias within the DSM, our attention must turn to the treatment of disordered conditions. If current treatment models in fact produce high recovery rates, then, regardless of the aforementioned issues, the understanding of mental illness posited by this perspective will be verified as appropriate or at least moving in the right direction. If such recovery rates have not occurred, however, then the mechanistic explanations cited for these conditions will be revealed as even less tenable. We will then be left with our three
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possibilities: the correct mechanism has yet to be identified and further investigation is required; multiple conditions have been conflated into one, each with possible multiplicity of causal mechanisms; or the conditions of schizophrenia and depression do not exist in the way that they are described in the DSM. Such revelations will be made possible through the results of several studies conducted by universities, the NIH, the NIHM, and the WHO.
Since the 1960s, countless studies have been conducted into the efficacy of the most predominant treatment model prescribed for both depression and schizophrenia, that of psychiatric pharmaceuticals. With regard to depression, the NIMH by 1969 had already determined that certain antidepressants known as monoamine oxidase inhibitors (MAOIs) had not proven effective when compared to placebo. In light of this, they decided to test the wonder drug, Imipramine, in the same fashion. In well-controlled studies, 61% of the drug-tested patients improved versus 46% of the placebo patients, a net benefit of 15%.15 Aside from the fact that such results were deemed unimpressive, the problem within the study was that only about 40% of the drug-treated patients were able to complete the 7-week study as the condition of the other subjects had deteriorated to the point they could no longer participate.
In 2001, the NIH funded a study to explore how the antidepressant Zoloft would compare not only to a placebo, but to an active placebo, St. Johns Wart. An active placebo is a substance that produces some side effect and is chosen for the purpose of creating a blind study. In the results, 24% of patients had a full response in the St. Johns Wart Group. Comparatively, Zoloft produced positive results in 25% of the patients, and 32% of the placebo group reported positive outcomes.16 While St. Johns
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Wart did not prove itself to be an effective herbal remedy for depression, neither did the antidepressant, Zoloft. The placebo group reported the highest outcomes of the three.
Similar results were produced when medications that are classified as Atypical antipsychotics were tested in independent studies. Atypicals were the most recent wave of medications that had been introduced into the market for the treatment of depression and schizophrenia and include such drugs as Risperidal, Zyprexa, and Seroquel. These medications were purported to be more effective than their predecessors, as they were designed with the idea that perhaps multiple neurotransmitters are involved in causing mental illness. In 2005, NIMH conducted the Clinical Antipsychotic Trials of Intervention Effectiveness or CATIE trials comparing atypical medications, such as Seroquel and Risperidal with their predecessors (perphenazine). It was determined that there were no significant differences between the new medications and the old ones. Not only did the study reiterate that neither types of medication were effective, but it also showed that 74% of the 1,432 patients involved were unable to complete the trial due to either the inefficacy of the medications or the intolerability of their side effects.17
Beyond the fact that many psychiatric medications have not shown themselves to improve the course of recovery of these disorders in clinical testing, it has become clear that serious long-term side effects often result from taking them. Reports have emerged since the turn of the 21st century indicating that cellular death of neurons in the hippocampus, shrinkage of the thalamus, and abnormalities in the frontal lobe can all be traced to long term exposure to antidepressants and antipsychotics. Furthermore, these drugs have been identified as the verifiable causes of certain issues such as impaired
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memory, loss of creativity, blunted affect, fatigue, and learning deficiencies.18 Such symptoms only serve to exacerbate the condition for which these drugs are prescribed, directly impairing the individuals capacity to learn how to cope with distressing emotions and recover from such distress. Discoveries such as these reveal further implications for the essentialist strategy as such practices follow directly from this theoretical foundation; namely the belief that the purpose of clinical intervention is to treat deviated or malfunctioning mechanisms. However, as has been made clear, organic mechanisms remain unidentified as the cause of such illnesses.
Moreover, prior to the advent of the pharmaceutical revolution in psychology, phenomena classified as depression or schizophrenia were viewed as largely episodic, and in a majority of cases, resolved on their own. It was only after such pharmaceutical treatments came on the stage that these disorders began to be described as chronic conditions. The evidence for this can be traced first to German physician, H.P. Hoheisel, who had noticed by 1966 that intervals between depressive episodes appeared to be shortening in those exposed to antidepressants. Bulgarian psychiatrist Nikola Schipkowensky corroborated this poigniant observation in 1970, noting that most patients treated with tricyclics, such as Imipramine, were only ever partially cured. Symptoms would not remit fully in these patients and their depression would often return, worsening when the course of antidepressants was stopped.19 These insights were further validated when Robert Prien at the NIMH reported in 1984 that 71% of depressed patients relapse within eighteen months of drug withdrawal.20
Steve Hyman director of NIMH explains that the mechanisms that cause such withdrawals, which are often classified as psychological relapses and a resurgence of
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symptoms, are the direct result of compensatory adaptations in the brain having been triggered by these same medications. With exposure to psychiatric medications over time, the compensatory mechanisms that seek to counteract the drugs effects break down, causing long term and in some cases irreparable changes to the neuronal pathways. According to Hyman, it is only after a few weeks that the brain of an individual medicated with psychotropics can be said to be functioning in a manner that is qualitatively, as well as, quantitatively different from the normal state.21
This explanation was further substantiated by Italian psychiatrist Giovanni Fava in 1994. The compensatory effects caused by psychotropic medications were reported to be ever more profound, the longer an individual has been exposed to the drugs. In many cases, evidence has shown that a tolerance can begin to build up, requiring gradually higher doses, which in turn causes an ever greater physiological effect on the brain. Fava explains that when such pharmaceutical interventions are stopped these processes then operate unopposed, resulting in the appearance of withdrawal symptoms and increased vulnerability to relapse.22 The point that is made is that the longer an individual has been taking such medications, the worse the effects of withdrawal when the regimen is stopped.
American psychiatry has challenged these claims since the mid 90s, contending that long term outcomes are not caused by psychiatric medications, but are instead attributable to not having truly understood the course and presentation of mood disorders and psychotic illnesses prior to this point.23 The previous epidemiologic studies of the 1960s and 70s had been flawed, the APA states in their Textbook of Psychiatry. With the chronic nature of these illnesses now known, these conditions have been rebranded
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and are each described as highly recurrent and pernicious disorders.24 What had been considered episodic distresses with highly favorable outcomes not 50 years prior are now classified as persistent and debilitating diseases, requiring ongoing pharmaceutical intervention and maintenance to correct the balance of abnormal biology. It seems odd that such a significant shift in understanding could occur in the light of clear evidence to the contrary. The motivation however will become evident as the validity of this shift is put to the test.
Global Studies of Schizophrenia and Depression
Why then, in the face of studies provided by leading researchers in the field, would clinical psychology hold to a view that classifies depression and schizophrenia as chronic conditions? The reason for this is due to the fact that such diagnostic classifications are also the result of compiled studies. These clinicians work with clients diagnosed with mental disorders such as schizophrenia or depression. Through the course of clinical treatment some individuals may improve but very few leave the clinical system entirely. More often, clinicians observe these individuals return time and again either because of a resurgence of symptoms or difficulties with life. These individuals come to form the basis for clinical case study. The major difference, however, is that these conclusions are informed by what professionals have observed through this practical work rather than those that arise out of an experimental setting.25 Furthermore, these observations and conclusions are highly enshrined by mechanistic strategies for explaining the essentialist ideas around schizophrenia and depression.
To recap, this philosophy understands pathological phenomena as having been caused by deviated essential mechanisms. So long as the essential mechanism remains
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unaltered, the pathological phenomenon will continue to persist, presenting therefore in a chronic fashion. This model makes sense when compared with how certain conditions are understood in medicine. Complications in the structure of the heart will produce cardiovascular issues unless the heart is treated, however, the organic causes for mental illness offered by clinical psychology remain unverified. In the face of a growing body of research that suggests the chronic course of these conditions is likely the result of altered organic states from medical treatment, the chronic classification assigned to these conditions ought be called into question. A misunderstanding of the true course of a condition in turn presents its own obvious challenges to the capacity for clinical psychology to devise appropriate treatments. It is through a number of studies offered by the World Health Organization (WHO) that this debate can be resolved.
We begin with a 15-city international study conducted by the WHO, wherein patients were screened for depression and observed over a 12 month period to determine the course of the disorder. Of the 740 individuals identified with depression, 484 were not exposed to pharmaceutical treatment. The group that had remained unmedicated, according to the study, presented with the most favorable outcomes, reporting lower incidence of continued depression than the medicated group. The group that performed least favorably with regard to the persistence of symptoms were those treated with antidepressants, with more of these patients deemed to still be mentally ill than the unmedicated group.26
Yet another study out of Brown University in 2006 sought to test the poor long term outcomes for depression that had been claimed by syndicated APA textbooks rather than the more optimistic natural course described by earlier psychologists. The question
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of whether there might be a difference between medicated and unmedicated depression was posed. Michael Posternak identified 84 patients in NIMHs Psychobiology of Depression program who had relapsed following the cessation of antidepressant treatment, but had not resumed taking medication. 23% recovered in one month, according to Posternak, 67% in six months, and 85% within a year. This confirmed the initial prognosis of psychiatrist Emil Kraepelin from 100 years prior that untreated depressive episodes often resolve themselves within 6-8 months.27
In regard to schizophrenia, a meta-analysis was compiled by Giovanni de Girolamo at the Division of Mental Health at the WHO. In 1996, de Girolamo reviewed the results of nearly 30 years of study into the nature and outcomes of schizophrenia treatments around the world. The first study initiated in 1969 was called the International Pilot study of Schizophrenia (IPSS). 1,202 patients aged 15-44 were engaged through centers in China, Columbia, Czechoslovakia, Denmark, Nigeria, UK, USA, and USSR. 811 patients had been clinically diagnosed with schizophrenia and 391 had received a diagnosis of either affective disorder, psychosis, neurosis, or personality disorder. Following the initial clinical examination, patients were assessed at 2 years and 5 years. While IPSS concluded that schizophrenia can be said to be universal with regard to the profile presentations of positive symptoms (i.e., delusions, hallucinations, etc.), a high variability of course and outcome was noticed among the different countries.28
This variability was quite stark. Patients from the three poorest countries of the study (India, Nigeria, and Columbia) faired far better as a whole than patients in the US and other more developed countries. In Nigeria, for example, 57% of patients were in the group with best outcomes as compared to only 6% in this group among patients in
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Denmark. Of the patients in the worst group for outcomes, Denmark had 31% of patients, whereas Nigeria only had 5%.29 Across the countries, the results can be summed up thus: 64% of patients in the underdeveloped countries were asymptomatic, 12% were neither symptomatic nor fully recovered, and 24% were still doing poorly at the end of the IPSS. In the developed world, only 18% of patients were asymptomatic and well, 17% were in the middle range, and 65% continued to present with poor outcomes.30 A striking comparison also revealed that patients in developing countries more frequently presented with a single psychotic episode that then went into full remission, whereas the course for patients in the developed world was more often characterized by multiple episodes followed by periods of moderate symptom presentation.31
The second study sought to explain the findings reported in the IPSS. This time, centers in 12 countries engaged 1,379 participants with particular focus given to patients presenting with their first schizophrenic episode. The report replicated the findings of the IPSS. Two-thirds of patients in the third world presented with good outcomes by the end of the study with figures inverted for the developed world. Among other insights, it was noted that patients in developing countries seemed to have a higher incidence of acute onset of psychosis (49%), whereas developed countries reported a greater incidence of what they described as a slow and insidious onset of symptoms. One of the most compelling points revealed was that only 16% of patients from countries of the developing world were on antipsychotic medications and 55% had never been hospitalized. Alternatively, 61% of patients received some pharmaceutical intervention in the developed countries and only 8% had never been hospitalized.32
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From these multiple studies outlined in the meta-analysis, trends begin to emerge that have important implications for current clinical practice. In richer countries where 61% of the total patients were treated with psycho-pharmaceuticals, around two-thirds of patients reported to have the worst outcomes with a chronic experience of the illness. In poor countries, however, where 16% of patients were treated with antipsychotic medication and over half were never hospitalized, two-thirds of patients were reported to have had only one episode of the illness, and most had fully recovered. Of all of the factors that seemed to influence the course of schizophrenia in patients worldwide, one of the most statistically significant correlates seems to be access to medical care not for its efficacy, however, but because it seems to impede the ability of schizophrenic patients to recover. With reliable and replicable recovery rates reaching such heights as 64%+ over the course of 37 years of study, some of the study authors felt that the data challenged the concept of chronicity that had long been associated with schizophrenia. De Girolamo concludes that the integration of patients in a natural social environment, and the restriction of medical interventions to an indispensable degree may provide an optimal care strategy.33
Figures from numerous studies along with corroborated empirical data seem to reach the same conclusions. There does not seem to be sufficient, replicable data to show current models for the treatment of schizophrenia and depression to be significantly effective in the treatment of mental illness. Furthermore, there seems to be little evidence to support current theories that these mental conditions are caused by deviated organic mechanisms or that they follow the chronic course ascribed to them by the DSM. Such results certainly raise serious questions about the confidence that has been put into the
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medical treatment of mental disorders. Conventional treatment models that seek to treat
deviated organic mechanisms have been shown to produce poor recovery outcomes and are then ineffective methods for clinical treatment, which is not surprising as the identity of verifiable organic causes have remained elusive.
As this has been shown to be the case, we are then left with our three possibilities. It is entirely possible that we have arrived at these outcomes because, one, the correct mechanism still needs to be identified, which prompts the need for further investigation. Two, it is possible that we have conflated multiple conditions into one, and each of which may result from a multiplicity of their own causal mechanisms. And lastly, it could be that the conditions of schizophrenia and depression do not exist in the way that they are described in the DSM. First, however, a case must be made as to why we would be inclined to set aside the first two possibilities if we are to even entertain a non-essentialist alternative.
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CHAPTER IV
ESSENTIALISM VS POPULATION THINKING
As was discussed in Chapter II, the essentialist strategy has shown itself to be valuable in many fields of study and so we cannot reject it outright. We have seen the benefits that it has provided for physics, chemistry, and even medicine. There are, however, other disciplines where this approach seems to be less appropriate. In this Chapter, the challenges posed by this strategy to the fields of statistical mechanics, evolutionary biology, and ideas of health and illness will first be explored. In response to these issues, a non-essentialist alternative through population thinking will then be presented. Finally, the virtues of this alternative will be discussed along with the manner in which it is able to reconcile many of the anomalies that arise from the application of essentialism in the aforementioned fields.
To understand these challenges, we must first return to the essentialism of Aristotles Natural State Model (NSM). Following from the Aristotelian model, essentialism is understood as an explanatory strategy for identifying natural types and explaining diversity. Types are categorized by constituent properties that are both necessary and sufficient for membership in the type. These conditions are the reasons why a thing is what it is. Per this view, objects have natural states, where in an ideal environment, like will produce like. Variation is the deviated, unnatural state of an object that is the result of some interference. The obvious dilemma with this approach, however, is the innumerable examples of diversity that are observed in nature. What is the explanatory value of defining types by similarity when diversity is just as, if not more
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commonly the norm? It is just such cases, seen as anomalies, that reveal the greatest challenge to the essentialist strategy, namely the capacity to account for variance. Statistical Mechanics and the Law About Errors
The first example that I will cite where this challenge arises is the manner in which Aristotelian essentialism stymied the mathematical field of statistics well into the mid-19th Century. The view dominated the area of the law of errors, that is, the mathematical techniques by which sets of discordant observations could be interpreted.1 The problem to be solved for such techniques was to find the single true value of a variable in question amidst a sea of obtained inconsistencies. This was accomplished by taking the mean values of the observed variations, which when plotted on a graph generate a bell curve. The top value of this bell curve is then considered the true value, and is given privilege over the values of other observed variations, labeled errors. Any insights that could be gleaned from the observed variations are then lost, when these error values found on the distribution curve are discounted.2
Frances Galton revolutionized the study of errors in his explorations of heredity. Through the development of such measures as standard deviation and the correlation coefficient by which statistical analysis is now performed, Galton was responsible for fundamental innovations in the analysis of individual differences3 While his observations on heredity are weak and smack of an essentialist bias, he proposed that variation was not a result of some sort of interference that diverts values away from the type, understood as the true value at the top of the bell curve. Rather, the bell curve itself could be seen to represent a variance distributed across a single generation explained by a transmission of variability from the previous generation. The
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focus on the distribution of the bell curve rather than the obtained true value provided a means to statistically measure deviation. According to Gabon, this deviation does not depict mistakes in observation, but rather reveals the lawful and causal relations that exist in variability.4 Thus, the law of errors was replaced with what was termed normal law, as Gabon argued that bell curves can be observed anywhere, and are therefore real and can be considered normal.
Essentialism and Taxonomy
A second example is found in the field of taxonomy. Despite the acceptance of evolutionary theory, which explains how organisms change through alterations of inherited physical and behavioral traits, David Hull explains that ideas such as the static species concept persist. The idea of static species postulates that species are stable over time and reveals that the influence of essentialism lives on to pose challenges to the taxonomy of species. While this strategy can be helpful for the formation of concepts, Hull reiterates that it only works by way of pretending that certain properties are essential for the purpose of definition in the face of the immensity of diverse forms to be classified in nature. Hull argues that Aristotelian definitions fail when such theoretical concepts are transposed onto reality, and have impeded the ability of taxonomists to generate appropriate names for taxa.5 The reason for this is that a taxon, one or more populations of organisms that can be said to form a unit, can only be appropriate if definitions and distinct names are able to encompass the multitude of diversity observed within a group in nature.
However, what the Aristotelian definition attempts to do in modem terms is to describe a thing, be it an individual or group, by proposing properties that must be
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conjunctively connected. As previously mentioned, these properties are severally necessary and jointly sufficient.6 Darwins inquiries revolutionized this approach by first asking whether any form exists for membership in a category that is sufficiently constant and distinct from other forms to be capable of definition. Furthermore, even if these forms are definable, can the differences be sufficiently important to warrant specific names? On these grounds, Darwin ultimately rejects what he calls a vain search for the... undiscoverable essence of the term of species.7 Hull echoes that such Aristotelian definition can be discarded as taxa names cannot be defined by such conjunctively connected properties, for seldom is a property of any taxonomic value distributed both universally and exclusively among a taxon.8 They are not analytically connected, Hull continues, because an individual or population could lack any one or few of the properties and still be a member of the taxon.9
While it is clearly true that there are similarities within biological taxa, it is equally the case that persistent differences can be used to characterize many taxa.
Despite this fact, the essentialist view focuses on the idea that natural kinds are united by this similarity.10 In reality, however, selection brings about many cases of heterogeneous types that are distributed within a species-population (i.e., males and females, larvae, pupae, and imagos, etc.). The fitness of each type is then dependent on its frequency relative to the others.11 The core issue that is revealed for the essentialist view is that when privilege is given to similarity of individuals within species, the explanatory strategy becomes limited with its capacity to account for observed variation.
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Health, Illness, and Fitness
A more pertinent example for this thesis can be found in modem conceptions of health and disease in western medicine. Sober explains that this view, indeed, the very notion of normality as something other than a statistical average, enshrines the essentialist perspective. This point can be understood in that the essentialism of Aristotles Natural State Model seems to recommend such distinctions of function and dysfunction. As stated, objects are said to have particular dispositions or natural tendencies, indicative of their essence. The expression of these tendencies is contingent on environmental forces that will either manifest what is natural, and therefore healthy and normal, or interfere, distorting that nature.12
Put in biological terms, the essentialist defines a species-type in terms of certain traits that are shared by species members. These traits can be understood as the phenotypic, or observable expression of underlying genotypes (genetic essences) that constitute the individual members. It is in an ideal or natural environment that these particular natural traits will express.13 As such, this view requires that this ideal environment exist, devoid of interference, as the necessary condition for the optimal and healthy expression of each trait. The most obvious problem with this point, Sober explains, is that no such optimal environment exists in nature, as any given environment is subject to a range of potentially interfering forces at any given moment.14 If no such optimal environment exists in nature, then how are we to ascertain what this measuring stick of health and normality would look like?
A further concern arises from the conflation of ideas that what is undeviated or natural is healthy and therefore good. At issue here is the privilege and preference
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given to the natural, undeviated state of an object. As evolutionary biology reveals, however, there is a range of traits that can be observed in nature that can include varying degrees of health and disease. Not only are these traits normally distributed across populations, but each can have an effect on the fitness of its respective organisms.15 Fitness, understood as more than simply the ability to produce offspring, is the ability of organisms to fit within their environment by means of survival and adaptation. Fitness is then characterized, according to Sober, as a relationship of an organism to its environment.16 Contrary to such features observed in nature, the essentialist idea that organisms have natural tendencies dictates that there are properties that an organism is supposed to have regardless of its environment. Such a view would certainly justify distinctions of functionality and dysfunction, however the problem is that such demands are inconsistent with what is understood about maximal fitness of organisms.17
Sober explains that for any given trait, there are environments in which it can be selected for or against. What this means is that for every trait there are environments where the trait will promote an organisms ability to survive and procreate and environments where it will hinder this capacity. The problem that arises for this essentialist distinction is that, depending on the environment, nature reveals that diseases can prove advantageous, while health can represent a cost to the overall capacity of an organism to fit in said environment.18 These are just a few explanatory limitations that an essentialist distinction of health and non-health puts on our ability to understand concepts of health and disease in nature.
In this light, the essentialist views of species, along with health, can prove somewhat problematic. For most species, we know that there are a multitude of genetic
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recombinations possible through sexual selection, as well as phenotypic expressions that can emerge in response to a given environment. To define members of a group or states of health in such restrictive terms seems problematic, to say the least. In fact, given the immensity of such possibility, one might expect to see even greater diversity than is observed in nature. What is discovered, however, is that ranges of both genotypes and phenotypes are distributed across these groupings normatively, as represented on a bell curve. This is what is termed the norm of reaction; a means by which different genetic results can be measured and depicted as they emerge in differing environments.19
This brings us back to an idea of normality, although, this time as a statistical average. Far from problematic, this view of normality is quite useful for Sober, as it begins to shift the focus away from characteristics of individual organisms to patterns observed in the larger group. The limitation of the essentialist strategy to explain the diversity found in nature, Sober explains, is due to this focus on individual characteristics as they are used to define an overall type-norm. When the observed components of the individual are compared to the overall type, it is easy to see how ideas of normality and abnormality might arise. The issue, however, is that the actual norm in species is the diversity among individuals, which is left largely unexplained by essentialism. By transposing the focus to a higher level of organization, population models, as utilized in evolutionary biology, can better able to account for this diversity.20 Population Thinking
Rather than searching for the invariant properties possessed by all individuals of a type as with essentialism, population thinking is an alternative explanatory strategy that seeks to specify laws and forces that govern and influence how this variance is distributed
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across a population of a certain kind.21 Where the population is set as the focus above the individual, factors that influence the structure of this diversity are of central concern, rather than uniformity where homeostasis is mistakenly presumed as the norm.22 It is not a matter of finding the similarity of a proposed underlying reality amidst diversity, but the reality that is sustained by diversity. Since the members of a population are taken to be unique, shared similarities are viewed as unexpected and therefore become the features that require explanation 23 The essentialist demand for constituent definitions of species is made unnecessary by comparison to the populationist view due to the greater explanatory value of the latter in accounting for variance.24
Let us develop this understanding of populational thinking further. As stated, the populationist puts the focus on the group, rather than the individual. By taking the individual for granted, the varying possible traits can be observed as they are distributed across the group. Though somewhat arbitrary, the population can be defined as any grouping of objects that are pertinent to a given line of inquiry, be it an ecosystem, species, or residents of a city, etc. Now, for the essentialist, traits that define type membership must remain constant and unchanging regardless of time and circumstance, whereas this spacio-temporal context is crucial for population thinking 25 With a particular group set, the populationist can observe how various features and dynamics of the group shift or remain stable (i.e., group size, demographics, fitness, sexual selection, etc.) over different points in time.
A populational model can be understood as follows: We begin with a population designated X, which is observed over the course of n time segments (Tl, T2... Tn). Over these time periods, members of the population will die or leave and be replaced by new
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members. As a result of this member replacement, population X will not be composed of the same members at each time segment. This is not problematic, however, as similar distributions of possible features can be expected within the groups due to the norm of reaction. The groups can then be differentiated as population Xi, X2... Xn, respective to their designated time segments. Upon observation, features will shift or persist across these segments of time and amidst the underlying diversity. Similarity here is unexpected, however, as the expectation would be greater diversity given the influence of member replacement. Despite this expectation, stable features (Fi) will emerge. The populationist then seeks to identify factors from the external environment and within the dynamics of the group that contribute to and explain the persistence of such stability.26
Depending on the subject matter in question, the populationist view can be chosen over the essentialist view on explanatory grounds alone due to the greater capacity in accounting for variance. Moreover, it is this greater explanatory capacity that allows the populationist to better describe and explain phenomena and systems that exhibit dynamic and adaptive features due to the multitude of both internal and external pressures to which they are exposed. As such, they express with a high degree of variability often giving rise to emergent properties which themselves do not always follow a linear logic that is characteristic of the essentialist strategy.27 It is just this degree of variability that the strategy of population thinking is designed to explain.
The point of this is not to prove essentialism false in regard to health or species, or any other classification. It is entirely possible, however unlikely it may be, that species do in fact possess unified essences that make up what they are. The point here is to show that there are alternative explanatory strategies that under certain circumstances
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are more appropriate for describing some phenomena in nature. What is most important is the explanatory value of the strategy. Which explanation tells the best story? Which approach leads to greater levels of inquiry? Following the principle of parsimony, whichever strategy provides a more inclusive account for the phenomena in question is the strategy that should be given preference.
To this point, we have seen how essentialism has influenced the understanding and treatment of schizophrenia and depression in the DSM. Suspicions have been raised with regard to the validity of those explanations through the citation of numerous clinical studies and suspicions raised as to the appropriateness of the essentialist strategy in this context. Moreover, fundamental problems have been exposed when this strategy is applied globally to particular fields of science due to limitations when accounting for variance found in a range of phenomena. Lastly, a non-essentialist alternative through population thinking has been presented that has since made essentialist strategies unnecessary with regard to the study of certain living systems.28 With the groundwork laid, we can now explore what insights a non-essentialist alternative might provide for our understanding of mental conditions, such as schizophrenia and depression.
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CHAPTER V
THE NON-ESSENTIALIST BRAIN
From the previous chapters, we have found both theoretical and practical reasons to be suspicious of a globalized assumption of essentialism as the best way to explain observations in mental pathology. This does not mean, however, that there are not essentialist answers that could be discovered for such conditions. What then might incline us to abandon such lines of thought? As stated before, one such reason is that despite repeated efforts, progress has proven stubbornly slow towards the justification of claims that schizophrenia and depression are the result of unified, dysfunctional mechanisms. Such stagnation is made all the more curious, given successful progress in other fields like the cognitive sciences.
Central to this issue, I would argue, is the understanding of the brain that is implied in the DSM. The definition of mental disorders refers to the dysfunction among mechanisms that underlie mental function. Not only are non-essentialist explanations for such conditions precluded, but it also implies that the brain is to be understood as a composition of mechanisms. This view is further supported by the range of contemporary theories offered along with decades of scientific experimentation which firmly seat these pathologies in the brain. The problem, however, is that observed operations in brains do not seem to lend themselves as readily to mechanistic explanation in the same manner as other organs, like hearts, lungs, and livers. I argue that it is this mechanistic understanding of the brain that compounds the previously mentioned challenges to understanding schizophrenia and depression.
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If we are to offer a non-essentialist alternative for the understanding of the above conditions, it may be necessary to understand the brain in a different way, as well. With this alternate conceptualization offered as a foundation, it may then be possible to provide more fruitful accounts for the diverse presentations observed with both schizophrenia and depression. To do this, a basic understanding of the brain will first be provided. The brain and its activities will then be described through the non-essentialist alternative of population thinking. With this model of the brain developed, the populationist strategy will finally be applied to the features of schizophrenia and depression in the larger population. What implications this approach might reveal for the understanding of these conditions in the DSM will then be explored.
Understanding the Brain
To begin, we must first look at what is known of neurophysiology. The adult human brain is composed of around 100 billion neurons, as well as a number of other kinds of cells. Each neuron receives messages from a web of connectors, called dendrites, and it sends messages through a single terminal called an axon. These messages engage the release of various neurotransmitters (dopamine, serotonin, norepinephrine, etc.) into the space in between connected neurons, called the synaptic cleft.1 A single neuron has between one thousand and ten thousand synaptic connections, which means that the adult brain is connected by somewhere around 100 trillion synapses.2 Given the capacity to perform tasks of creativity, reasoning, coordination, memory, and language, while simultaneously regulating the myriad physiological functions required to keep humans alive, the immense complexity observed in the brain is staggering with. In attempts to explore essentialist sources of mental conditions,
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however, the profound multifariousness of these many functions is often oversimplified in the search for unifying disease mechanisms.
This is not to say that the brain itself does not have its own mechanisms or that their understanding eludes our grasp. There is, in fact, a great deal that we understand about the mechanisms of the brain. We have identified the different components of the neuron and understand how neurons communicate with one another. At the time of neurogenesis in developing brains, we know that stem cells divide and produce both another stem cell and a neuronal precursor, the neuroblast. The leaving of this cycle of cellular replication defines what is called the neuronal birthdate of the resulting neuron.3 We have also learned how, in the fascinating process of dendritic arborization, growing axons can reach over millimeters and even centimeters to seek appropriate synaptic partners.4
Equally, we are able to identify features of the brain on a larger scale. As previously explained, dopamine has been identified as a neurochemical that is involved in such processes as motor function, emotional regulation, and higher executive functions associated with personhood.5 Furthermore, we are able to map how the dopaminergic system spans multiple regions of the brain. It is known that Brocas area, for instance, which is found in the front third of the left hemisphere, is highly involved in language comprehension.6 We are aware that sensory perception is invested with emotional experience through the amygdala.7 However, despite these facts, such information does not tell us much about the mechanisms that make these higher-level features possible. Such descriptions point to little more than geographical locations in the brain that seem to light up in brain scans when individuals are engaged in various activities.
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The fact that we have yet to identify how the mechanisms of singular or even groups of neurons produce these higher-level phenomena is not a reason to abandon the essentialist approach, however. There are many cases where complex mechanisms operating at different hierarchical levels of organization give rise to emergent properties. It is just such examples that could account for the phenomena that are observed in the brain. While population thinking does not preclude mechanisms, the question to be asked is whether a mechanistic model alone is the best strategy for describing phenomena that are observed with the brain or whether another approach might allow for more inclusive and fruitful explanations. Ecology may provide an example that could inspire us to explore the brain in this new way.
Viewed in an essentialist manner, any given ecosystem is constituted by a plethora of individual components, just as the brain is composed of billions of neurons, glia, and other cells. Each of these ecological members are subject to a myriad of factors including climate stability, fitness, sexual selection, access of resources, predator-prey dynamics, and so on. Equally, the brain is influenced in both its development and ongoing life span by a range of factors from both within and without. Furthermore, it is possible to describe the mechanisms behind many of these features for both cases. However, given the interaction of this multitude of mechanisms and the adaptability of many of its component parts, ecosystems often present with a high degree of variability. The brain can also be seen to exhibit high levels of diversity in its expression.
The difficulty here is that not all of the observed variability in either ecosystems or brains will lend itself to obvious explanation through the description of these constituent components. As previous stated, this is a feature common to essentialist
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explanation. It is not that essentialist or mechanistic explanations are wrong in these cases, but simply that they have proven limited in their capacity to explain certain phenomena where diversity is present. In ecology, for instance, population models can be offered to account for the diversity that is often observed across highly adaptive systems. Such an approach may prove beneficial for understanding the brain.
A Non-Essentialist Alternative
It is for this and the reasons mentioned in the previous chapters that I argue a non-essentialist approach is worth exploring and describing brains in this manner is in no way novel. I will now present how the brain could be understood in a populationist context. I postulate that the system of the brain can be understood as a population of interrelated neural connections, in much the same way that evolutionary biology views populations of species. A crucial point to the populationist approach is that it applies to one specified population at a time, just as with species or ecosystems. Therefore, insights gleaned from one population (species or otherwise) are particular to a spatio-temporal context and may not necessarily translate directly to the insights of other populations even of a similar type. This model will then be used to describe the population of these neurological connections found in the human brain of singular individuals. This is not to say that there are not salient features that are shared by brains of the larger population; indeed, there would need to be something shared to be able to generate any sort of diagnostic criteria.
It is merely to point out that each neural population will reflect certain idiosyncrasies with regard to formation and structure. Before this point is clarified further, it would be beneficial to first present the model.
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To begin, the population is set as the approximate 100 trillion synaptic connections that are found in an average human brain. Similar to populations of species, the strength of neural connections are subject to member replacement. As the strength of certain connections weaken, they are replaced by the signal strength found in new distinct connections. As these members are replaced, a distribution of possible features can be expected across the population as is anticipated by the norm of reaction. Signals and connections between neurons change or strengthen across the lifetime of the population and, just as with species, are subject to genetic and environmental pressures. As such, neural signaling patterns can be seen to be historically rooted in the particulars of the individuals genetic, experiential, and ontogenic development. With these conditions and dynamics present, it seems plausible that a populationist strategy, as it is utilized in evolutionary biology, might provide a well-structured model for understanding the brain. As an example, this strategy will be applied to the features of learning and neuroplasticity.
Neuroplasticity is the idea that the brain can alter its organization in response to various experiences and can be seen as the neural correlate of memory and learning.8 This process involves changes in the signal strength between networks of existing synapses.9 This plasticity of connections between neurons allows us to explain how stable features emerge and change in larger neural networks, both in the short and longterm. In response to an altering of inputs (genetic, ontogenic, environmental, or experiential), the pre-synaptic terminal is first stimulated by action potentials in close succession. Once a critical threshold is reached, neurotransmitters are released into the synaptic cleft that both activate potentiation in particular pre-synaptic cells and also
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reduce inhibition of targeted post-synaptic cells. Over the course of milliseconds to months, the signals between initial neurons weaken as connections to the target neurons strengthen.10 At this point, activity in pre-synaptic cells drops off and inhibitive neurotransmitters are released to secure the newly formed connections. In terms of the population model, plasticity can be depicted in such a way that reveals many insights to how, for instance, new skills become stable features in the neural population.
For the purposes of this example, I will describe the process by which a piano player learns a new song, which interestingly enough, can be observed through imaging after certain dyes are injected into neural cells. Population X will be set as the neurological connections found in the brain of a piano player. Prior to listening to the new song or seeing the sheet music, the population shows one stable set of connections among neurons. The player is then exposed to the new song and population X is observed at time slices 1, 2, and 3. Changes are observed in the signal strength between previously stable connections along with an increase of activity in new synapses. As the song is learned, signaling patterns create something like attractor wells and new connections begin to form in the population. As a result, at time slices 4, 5, and 6, the new synaptic connections will have become relatively stable. What can be said is that there has been an observed phenomenon in population X wherein one stable signaling pattern has been exchanged for another. Insights can then be gleaned from an exploration of this learning process and how it has been influenced by other possible factors.
First among these are genetic and ontogenic elements, which could represent either deficits or advantages. Each with their own biological and environmental factors would affect not only the critical threshold of action potentials required for potentiation
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but also the capacity to stabilize newly acquired features. Second, there are experiential factors. A short potentiation period may reflect that population X has previously developed certain associative neural networks with regard to this skill. Put simply, the short period may be due to the fact that the individual is an experienced piano player. This foundation would facilitate a lower threshold for action potentials and more efficiently facilitate that change in signal strength between connections. Equally, a longer period may be indicative of a novice player where associative networks among motor neurons need more time to form. A third factor could be the effects of immediate environmental factors outside of the population. How much the player has access to practicing a piano will affect the frequency of initiating action potentials. The difficulty of the piece might indicate the need to develop more motor connections during the process. Does the player have an effective teacher to facilitate this learning process? All are lines of inquiry that can shed powerful insights on the observed phenomenon through the populational model.
Schizophrenia, Depression and Population Thinking
Before this strategy can be applied to the conditions of schizophrenia and depression, it is important to first remember the essentialist manner in which each are understood in the DSM. Each condition is identified by a particular set of features, a symptom profile, which according to the definition of mental disorders indicates the presence of an underlying dysfunction. The identity of schizophrenia and depression are not these associated symptoms sets, but are themselves the dysfunction of mechanisms that constitute the brain. For population thinking, which it ought be noted is not in competition with a mechanistic conceptualization of the brain, the focus is now on
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populations of neural signaling patterns. Rather than being concerned with the function or dysfunction of constituting mechanisms, the population approach takes diversity as the norm and seeks to account for the emergence of stability in the neural population. With regard to schizophrenia and depression, the populationist will treat the observed symptom sets associated with the conditions as the stable features that require explanation. Instead of searching for causal mechanisms, constraining elements and contributory factors are then sought for the pragmatic reasons of accounting for the stability of these features.
To better illustrate this I will offer a populationist description of how symptoms of hallucinations (H) could become a stable feature in the neural population of an individual diagnosed with schizophrenia (Pop S). Say for Pop S, the symptoms of H do not emerge until age 27. Pop S is observed by a psychiatrist at times 5, 6, and 7 during the course of more than six months, thus attaining the diagnosis of schizophrenia as described by the DSM. H is now seen as a stable feature of Pop S and continues to be observed at later time slices of observation. However, prior to 27, Pop S did not exhibit symptoms of H. So Pop S5, S6, and S7 have feature H, but Si, S2, and S3 did not.
Inquiring into the various factors to which Pop S was subjected may perhaps lead to insights that could explain the emergence of feature H.
Studies have shown a strong correlation between heredity as well as obstetrical trauma that increase risk factors for the later development of schizophrenia. Are any such factors present in the history that may predispose Pop S toward feature H? Perhaps there were early childhood traumas (i.e., virus or abuse) that somehow effected the ontogenic development of the overall population. Prior to the emergence of H, were there any experienced traumas such as the death of a loved one, homelessness, physical
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violence (i.e., rape or assault)? Certain pathogens such as neurosyphilis can contribute to the emergence of H, for instance. Was Pop S exposed to any environmental elements that could explain the feature? Equally, are there factors that may contribute to the persistence of feature H such as might be the case with inappropriate therapeutic intervention? By approaching the brain as a population of neurological connections rather than as a dysfunctional mechanism, none of these lines of inquiry are taken for granted. Through the exploration of factors that influence Pop S, a story begins to form about how feature H may have emerged and also why it may persist.
The populationist strategy for describing brains not only has this capacity to explain the variety of symptoms of schizophrenia and depression in individuals, but also the many anomalies that emerge from the global assumption of essentialism found in the DSM. By focusing on the genetic, ontogenic, and experiential elements with which a population of neural connections are entangled, one can account for the individual presentations of each condition. It may be possible to understand why one individual with schizophrenia has positive symptoms of hallucinations and delusions, while another suffers from catatonia. Through this approach, it would be possible to explain why two people with depression exhibit 5 of 9 symptoms but only share one symptom in common. This model can lead to accounts for why certain people experience only a single episode of either condition followed by spontaneous recovery while others struggle in a more chronic fashion. Furthermore, one could reasonably account for the diversity in response to treatment; why medications work for one person while psycho-social models work for another.
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Before jumping to any conclusions that the populationist strategy in and of itself could reconcile the previous issues of essentialism in the DSM however, there is one point to be made. Aside from the definition of mental disorders that precludes the possibility of non-essentialist explanations, this populationist model only speaks to individual populations of neurons. At this level of inquiry, this model raises questions about what can and cannot be inferred across brains. As such, inferences made from one neural population to another could prove limited in a sense. This is not to say, however, that there are not features shared by the larger population of human brains.
The point to be made is that if our best model for the brain is an adaptive population of neural signaling patterns, then each set of neural networks that form by adulthood are the result of an indeterminant number of micro factors. These factors will reflect the variant genetics between individuals, ontogenic development including the variable influences of early learning, pruning, and environmental stimuli, personal experience, as well as socio-environmental impacts later in life. If this model is to be believed, then the tenability that all cases of schizophrenia or depression are the result of unified sets of dysfunctional mechanisms can be called into question. As such, it could be said that the conditions of schizophrenia and depression as they are described in this essentialist sense by the DSM do not exist. However, there would be no point in utilizing this model if the end result was classificatory nihilism, or at best a science of single minds. In order to reject the previously held conceptualization, a viable alternative must be offered that matches the level of explanation. To avoid this pessimistic end, it would be beneficial to once again turn to ecology.
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The manner in which this question of inference applies can be understood by looking at bats and pigeons. Bats and pigeons both have wings and the capacity for flight. For this reason, one might be tempted to make direct inferences between a bats wing and a pigeons wing, but there are a few issues here. First, bats are mammals which follow a distinctly different path of evolution than birds. Given the genetic and ontogenic differences of these two classes of animals, we notice certain differences in the bone structure and outward composition of each set of wings. Upon further inspection, it is revealed that each creature performs the act of flight in different ways. Largely due to these differences in structure, bats do not flap their forelimbs whereas pigeons do. Because of the differences of genetics, historical lineages, and wing structure and usage it would be difficult to explain facts about bat wings directly from facts about pigeons.11
This does not mean, however that there is nothing to be inferred and learned from the existence of these two types of wings. In fact, ecology depends on the possibility of inference across diverse populations. Population thinking in this sense, allows us to view features that are present across drastically different populations and explain what pressures contributed to the development of these similar traits. In the case of pigeons and bats, the populationist strategy can help to explain what factors influenced bats to develop the specific types of wings that they did and the same for pigeons. Equally, when the approach is applied to the larger population of flying creatures, constraining and contributory factors can be identified that have moved these diverse populations towards the stabilized feature of wingedness.
Classifications like species, predator, prey, as well as features of abundance, depletion, extinction, etc. are all elements that can be described and inferred across
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ecological populations at different times. This is one of the most important benefits that population thinking provides for ecology. The approach allows for the ability to not only identify these features and types across diverse populations but also through the observation of statistical frequencies, predict under which conditions these features could be expected. It is in this way that species can be viewed as classificatory kinds without the need for essentialist explanation. Due to factors as diverse as adaptation or genetic drift, organisms can vary from the expected species type, while still being considered part of the species. Equally, features such as extinction become an explanatory kind without the need for an essentialist basis. With features of an ecosystem such as extinction, there are many factors that could contribute to the phenomena while the feature itself remains stable. What is important here is that both organisms and phenomena can be described as classificatory kinds that are observed as stable features in different populations.
Analogously, there are equal benefits to utilizing the population model in psychology. Due to the idiosyncrasies of each individuals development, it has been stated that dispositions or behaviors that are explained for one neural signaling population could not be extrapolated to directly describe the specific features that emerge in another population. It could be argued, however, that the diagnostic thresholds used for the classifications of schizophrenia and depression could be used to identify stable features of the phenomena that are shared across the larger population. After all, it would be ridiculous to deny that people get sad. Sadness is a phenomenon that spans the larger population of human brains. Sometimes it is experienced for long periods of time, and sometimes to a debilitating degree. It is equally true that most auditory hallucinations
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among groups of individuals that experience them are reported as the hearing of voices. The point here is that the presence and stability of these observed phenomena can be accounted for, at least for an individual neurological population, without the need for an essentialist basis. However, how do we speak about these conditions in the absence of the essentialism proposed by the DSM?
It is possible through the populationist model that this idea that symptom features are merely the identificatory factors of underlying conditions can be set aside. Such a perspective could account for these symptoms in a new light thus allowing us to inquire about such phenomena in the larger human population. In this way, it would then be possible to revive the categories of schizophrenia and depression. In the absence of an essentialist basis, the identity of each classificatory kind would simply be understood as the observed features (symptom sets) that are shared across the larger human population. The populationist strategy would then need to be applied in a different way. Whereas the first application of the strategy was helpful to address questions about certain symptom features in individual brains, the line of inquiry is now concerned with what features or frequency of features are stable among populations of people that experience the phenomena of schizophrenia or depression as they are newly defined.
The benefit that this approach could provide for the larger population is the possibility to identify broad factors that move certain neural populations towards the emergence and stabilization of the feature sets that constitute these classifications of schizophrenia and depression. While such factors could not be assumed, they would lead to the discovery of certain statistical probabilities that would then inform clinical practitioners in their investigations of individual patients. Absent of an essentialist
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grounding, an understanding of the influential factors that give rise to these features could make it possible to then develop treatment models that would be tailored to the particular idiosyncrasies of individual populations.
Summary
It has been shown through previously elucidated studies that the search for essentialist mechanisms to explain schizophrenia and depression has born little fruit. Moreover, attempts to essentialize these conditions have led to anomalies with regard to variability of symptom profiles, course of illness, and diverse response to treatment. Acknowledging that it is possible that such mechanisms do exist, an essentialist basis for schizophrenia and depression has yet to be reliably identified that can accommodate these explanatory challenges. While composed of trillions of connected micro-mechanisms, it may prove more effective to understand the brain more as a complex dynamic system of neural signaling networks, given the profound integration of hierarchical levels as well as the high degree of interaction with a range of variables. Rather than attempting to decompose the brain into this multitude of constituent mechanisms, the populationist approach can offer a view of the brain as a population of neurons subject to a range of genetic, ontogenic, experiential, and environmental influences.
With regard to the conditions of schizophrenia and depression, this model could account not only for the various symptom profiles of the respective conditions, but also many of the anomalies that are observed through the application of a global assumption of essentialism in the DSM. While this first step may on its own provide a more inclusive account for these phenomena, it must be noted that the populationist approach to brains applies directly to individual populations of neural signaling patterns, due to the
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idiosyncrasies that result from the particular developmental pathways of each individual population. Inferences can be made, however, about the stable behaviors by which schizophrenia and depression are identified, thus removing the necessity for a unified essentialist basis for these conditions. Moreover, we see through population thinking that it is possible to generate classificatory kinds in the absence of this essentialist basis. In this light, the phenomena of schizophrenia and depression could then be defined directly by their associated symptoms. This would provide a foundation on which the populationist strategy could be applied to members of the larger human population. If the application of the populationist strategy proves more parsimonious in accounting for these phenomena at the human level, then we have reason to question whether the types of schizophrenia and depression, as categorized by the DSM, can be said to exist as essentialist kinds.
If the above is accepted as even reasonable, then it can be said that absolute confidence in the view of schizophrenia and depression as essentialist kinds has been undermined. Doubt would then be cast on this global assumption of essentialism as it pertains to the categorization of mental conditions in general. This is not to say that the DSM must be discarded, however, or that essentialist explanations do not attain for some conditions. It is merely to say that it would no longer be possible for the DSM to universally assume essentialist claims of pathology. As such, further engagement with the DSM ought to follow first from empirical justification for each category of pathology that it seeks to describe.
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CHAPTER VI
SUMMARY AND CONCLUSION
The primary purpose of this thesis was to cast doubt on the global assumption of essentialism with regard to pathological categories in the DSM. To do this, it was first necessary to undermine the universality claim of mental condition as essentialist kinds. I chose to focus on the two examples, schizophrenia and depression. The structure of the argument was constructed in the following four parts: First, a theoretical presentation of essentialism; second, a critique of essentialism; third, the presentation of a viable non-essentialist alternative; And fourth, the application of the populationist view for brains with regard to schizophrenia and depression.
The argument began with a development of the essentialist explanatory strategy which is used to individuate categories by necessary and sufficient conditions. Such conditions are treated as the underlying mechanisms that cause observed similarities of category members. Variance is thus accounted for as the result of interference or malfunction of the causal mechanisms. A description was then provided for how the essentialist view has been applied to the DSM and the conditions of schizophrenia and depression. Following this, I explained the predominant theories that persist; namely, that these conditions are the result of an imbalance of neurochemicals, genetic anomalies, or malformation during ontogenic development.
Challenges to these theories and their corresponding treatment models were then offered through the results of various studies spanning the past 70 years. Rather than substantiating these theories, the bulk of research at best indicated unexpected results with regard to presentation of symptoms, course of illness, and diverse response to
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treatments. These results alone, however, were not sufficient to prove essentialism in the DSM wrong. We were then left with one of three possibilities. One, the correct essentialist mechanisms for schizophrenia or depression have yet to be identified, requiring further investigation. Two, the anomalies are the result of conflating multiple illnesses that each arises as a result of their own essentialist mechanisms. Or three, that schizophrenia and depression as they are described in the DSM do not exist.
Theoretical and practical challenges that the essentialist approach has posed to categorization in other fields were then presented. What was revealed through this critique is that with regard to certain phenomena, essentialism presents a limited capacity in accounting for variance. A non-essentialist alternative was then offered through the explanatory strategy of population thinking. This is a strategy that describes a distribution of diverse features or phenomena as it can be expected across a population. Rather than seeking the similarities shared by individual members, variance is taken as the norm. Stable similarities then require explanation and can be accounted for through the influence of various pressures enacted on the population. Models were then described where this approach has been effectively utilized, including the field of evolutionary biology.
A case was then made for how this approach could provide a more clinically advantageous model of understanding the neural signaling systems of brains as individual populations of interrelating neural connections. With an alternative view of the brain provided, a new understanding of schizophrenia and depression was then offered without the need for an essentialist basis. It was postulated that these conditions could be redefining directly by their experienced symptom sets. On the explanatory basis of these
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new definitions, a populationist model was then proposed for how schizophrenia and depression could be investigated in the future. Due to the possible greater capacity in accounting for the anomalies found in previous studies of schizophrenia and depression, it was argued that the populationist view presented certain advantages over an essentialist understanding of these conditions.
If the populationist alternative is accepted, then unified essentialist explanations for these conditions become problematic as each individual population is the distinct result of a diversity of ontogenic factors. Inferences can be made, however, about the stable behaviors by which schizophrenia and depression are identified, thus raising suspicion about the necessity of describing these conditions on an essentialist basis. If the populationist strategy proves to be better at accounting for the phenomena in question, then we have reason to question whether the types of schizophrenia and depression, as categorized by the DSM, can be said to exist as essentialist kinds.
It is important to note, that this is not to say that essentialist mechanisms do not exist. Nor that there are not some mental conditions that do result from essentialist mechanisms. Among these is the well documented condition, Klinefelters syndrome, which effects the physical and cognitive development in males as a result of having an extra X chromosome. Indeed, the essentialist causes of such conditions have been substantiated by empirical findings. However, if the previous argument is true for two major diagnostic classifications in the DSM, doubt is then cast on the universality of essentialist assumptions in pathological categorization. This is to say that if these populationist models represent a viable alternative, then essentialist claims of pathology
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can no longer be universally assumed and therefore, empirical justification would be needed for each category prior to engaging further with the DSM.
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CHAPTER VI
WORKS CITED
1. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental
disorders: DSM-IV-TR. Washington, D.C: American Psychiatric Association.
2. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental
disorders: DSM-V. Washington, D.C: American Psychiatric Association.
3. de Girolamo, G. (1996). WHO studies on Schizophrenia: An Overview of the Results
and Their Implications for the Understanding of the Disorder. Haworth Press. 213-231
4. Ereshefsky, M., Matthen, M. (2005). Taxonomy, Polymorphism, and History: An
Introduction to Population Thinking. Philosophy of Science. 27. 1-21
5. Hull, D.L. (1965). The Effect of Essentialism on Taxonomy Two Thousand Years of
Stasis. The British Journal for the Philosophy of Science. 15(60). 314-326
6. Hyman, S. (2010). The Diagnosis of Mental Disorders: The Problem of Reification.
Annual Review of Clinical Psychology. 6. 155-179
7. Matthen, M. (2009). Chickens, Eggs, and Speciation. Nous. 43(1). 94-115
8. Nicholson, D. (2010). Biological Atomism and Cell Theory. Studies of History and
Philosophy of Biological and Biomedical Sciences. 41(3). 202-211
9. Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts.: Sinauer Associates, Inc.
10. Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of
Prozac. New York: Wiley.
11. Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
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Science. 47(3). 350-383
12. Sober, E. The Two Faces of Fitness. (2001) In Singh, R. Thinking About Evolution:
Historical, Philosophical, and Political Perspectives (pp. 309-320) Cambridge: Cambridge University Press
13. Sterelny, K., & Griffiths, P. E. (2014). Sex and Death: An Introduction to Philosophy of
Biology. Chicago, HI: University of Chicago Press.
14. Symons, J. (2008). Computational Models of Emergent Properties. Minds and
Machines. 18(4). 475-491
15. Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100( 1 -3). 4-19
16. Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drags, and the
astonishing rise of mental illness in America. New York: Broadway Books.
17. Whitaker, R. (2010). Mad in America: bad science, bad medicine, and the enduring
mistreatment of the mentally ill. New York: Basic Books.
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CHAPTER VII
END NOTES
CHAPTER I
1 American Psychiatric Association. (2013). Diagnostic and statistical manual of mental
disorders: DSM-V. Washington, D.C: American Psychiatric Association. 20
2 Ereshefsky, M., Matthen, M. (2005). Taxonomy, Polymorphism, and History: An
Introduction to Population Thinking. Philosophy of Science. 27. 2
3 American Psychiatric Association. (2000). Diagnostic and statistical manual of mental
disorders: DSM-IV-TR. Washington, D.C: American Psychiatric Association. 229
4 American Psychiatric Association. (2000). Diagnostic and statistical manual of mental
disorders: DSM-IV-TR. Washington, D.C: American Psychiatric Association. 345
5 Symons, J. (2008). Computational Models of Emergent Properties. Minds and
Machines. 18(4). 487 CHAPTER II
1 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 354
2 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 355
3 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 361
4 Ereshefsky, M., Matthen, M. (2005). Taxonomy, Polymorphism, and History: An
Introduction to Population Thinking. Philosophy of Science. 27. 4
68


5 Symons, J. (2008). Computational Models of Emergent Properties. Minds and
Machines. 18(4). 487
6 Nicholson, D. (2010). Biological Atomism and Cell Theory. Studies of History and
Philosophy of Biological and Biomedical Sciences. 41(3). 205
7 Hyman, S. (2010). The Diagnosis of Mental Disorders: The Problem of Reification.
Annual Review of Clinical Psychology. 6. 163
8 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 239
9 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 49
10 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 58
11 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 59
12 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 252
13 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 260
14 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 70
15 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 266
69


16 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 267
17 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drags, and the
astonishing rise of mental illness in America. New York: Broadway Books. 70
18 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 241
19 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 241
20 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 245
21 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 246
22 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 267 CHAPTER III
1 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 71
2 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 73
3 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 74
4 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 76
70


5 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 6
6 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 7
7 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 6
8 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 8
9 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 9
10 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 9
11 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 13
12 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 10
13 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 12
14 Tandon, R. et al. (2008). Schizophrenia, Just the Facts: What We Know In 2008.
Schizophrenia Research. 100(1-3). 9
15 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drags, and the
astonishing rise of mental illness in America. New York: Broadway Books. 154
71


16 Whitaker, R. (2015). Anatomy of an epidemic: magic bidlets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 156
17 Whitaker, R. (2015). Anatomy of an epidemic: magic bidlets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 303
18 Whitaker, R. (2015). Anatomy of an epidemic: magic bidlets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 170
19 Whitaker, R. (2015). Anatomy of an epidemic: magic bidlets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 157
20 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 158
21 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 83
22 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 159
23 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 161
24 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 161
25 Shorter, E. (1998). A history of psychiatry: from the era of the asylum to the age of Prozac.
New York: Wiley. 305
26 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 165
72


27 Whitaker, R. (2015). Anatomy of an epidemic: magic bidlets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 169
28 de Girolamo, G. (1996). WHO studies on Schizophrenia: An Overview of the Results and
Their Implications for the Understanding of the Disorder. Haworth Press. 214
29 de Girolamo, G. (1996). WHO studies on Schizophrenia: An Overview of the Results and
Their Implications for the Understanding of the Disorder. Haworth Press. 216
30 Whitaker, R. (2010). Mad in America: bad science, bad medicine, and the enduring
mistreatment of the mentally ill. New York: Basic Books. 228
31 de Girolamo, G. (1996). WHO studies on Schizophrenia: An Overview of the Results and
Their Implications for the Understanding of the Disorder. Haworth Press. 217
32 de Girolamo, G. (1996). WHO studies on Schizophrenia: An Overview of the Results and
Their Implications for the Understanding of the Disorder. Haworth Press. 221
33 de Girolamo, G. (1996). WHO studies on Schizophrenia: An Overview of the Results and
Their Implications for the Understanding of the Disorder. Haworth Press. 225 CHAPTER IV
1 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 365
2 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 365
3 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 367
4 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 369
73


5 Hull, D.L. (1965). The Effect of Essentialism on Taxonomy Two Thousand Years of
Stasis. The British Journal for the Philosophy of Science. 15(60). 316
6 Hull, D.L. (1965). The Effect of Essentialism on Taxonomy Two Thousand Years of
Stasis. The British Journal for the Philosophy of Science. 15(60). 318
7 Hull, D.L. (1965). The Effect of Essentialism on Taxonomy Two Thousand Years of
Stasis. The British Journal for the Philosophy of Science. 15(60). 320
8 Hull, D.L. (1965). The Effect of Essentialism on Taxonomy Two Thousand Years of
Stasis. The British Journal for the Philosophy of Science. 15(60). 322
9 Hull, D.L. (1965). The Effect of Essentialism on Taxonomy Two Thousand Years of
Stasis. The British Journal for the Philosophy of Science. 15(60). 324
10 Ereshefsky, M., Matthen, M. (2005). Taxonomy, Polymorphism, and History: An
Introduction to Population Thinking. Philosophy of Science. 27. 7
11 Matthen, M. (2009). Chickens, Eggs, and Speciation. Nous. 43(1). 11
12 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 378
13 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 374
14 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 375
15 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 379
74


Sober, E. The Two Faces of Fitness. (2001) In Singh, R. Thinking About Evolution: Historical, Philosophical, and Political Perspectives (pp. 309-320) Cambridge:
16
Cambridge University Press. 309
17 Sober, E. The Two Faces of Fitness. (2001) In Singh, R. Thinking About Evolution:
Historical, Philosophical, and Political Perspectives (pp. 309-320) Cambridge: Cambridge University Press 310
18 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 377
19 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 374
20 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 381
21 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 381
22 Ereshefsky, M., Matthen, M. (2005). Taxonomy, Polymorphism, and History: An
Introduction to Population Thinking. Philosophy of Science. 27. 7
23 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 370
24 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 372
25 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 373
75


26 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 374
27 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 370
28 Sober, E. (1980). Evolution, Population Thinking, and Essentialism. Philosophy of
Science. 47(3). 381 CHAPTER V
1 Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts. Sinauer Associates, Inc. 7
2 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 68
3 Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts. Sinauer Associates, Inc. 517
4 Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts. Sinauer Associates, Inc. 527
5 Whitaker, R. (2015). Anatomy of an epidemic: magic bullets, psychiatric drugs, and the
astonishing rise of mental illness in America. New York: Broadway Books. 70
6 Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts. Sinauer Associates, Inc. 648 7Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts. Sinauer Associates, Inc. 698 8 Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.). Sunderland, Massachusetts. Sinauer Associates, Inc. 583
76


9Purves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts. Sinauer Associates, Inc. 575 wpurves, D., Augustine, G. J., & Fitzpatrick, D. (2004). Neuroscience (3rd ed.).
Sunderland, Massachusetts. Sinauer Associates, Inc. 582 11 Sterelny, K., & Griffiths, P. E. (2014). Sex and Death: An Introduction to Philosophy of Biology. Chicago, HI: University of Chicago Press. 200
77


Full Text

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PAGE 4

\001\003 \002 \002 \004\001\002\010\011\007\012\013\007\006\012\014\004\011\014\004\003 \007 \006\015\001\016\004\011\005\003 \007 \006\026 \001 \006\004\005\022\015\013\036\017\005\006\015\004========\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026 \026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026\026 \026\026 \026\026\026\026\026\026\026\026\026\026\026\026\026 \001 \006\006\026 \001 \002\003\003\002\004\005\006\007\010\006\003\011\001\007\004\013\001\005\012\002\001\013\003\011==========\026\026=\026= \026\026 ==> \001 \007\026 \001 \006\004\005\022\015\013\036\017\005\006\015\004\001\005\015\001\002\003\003\002\004\005\006\007\010\006\003\011======== \026 = \026=\026\026\026 > \001 \023\026 \001 \005\012\002\001\011\002\017\012\007\004\006\003\005\006\017\001\003\005\022\007\005\002.?\001\025\015\022\001\002@\021\010\007\004\007\005\006\015\004\026\026\026 = \026 =\026 \001 \017\026 \001 \002\003\003\002\004\005\006\007\010\006\003\011\001\006\004\001\005\012\002\001\013\003\011====\026======== \026 =\026\026\026A \001 \013\026 \001 \003\036\011\011\007\022?=================\026=== =\026\026\026 \001 \006\006\006\026 \001 \017\015\004\005\002\011\021\015\022\007\022?\001\005\012\002\015\022\006\002\003\001\021\036\005\001\005\015\001\005\012\002\001\005\002\003\005\026==== \026 ==\026&' \001 \007\026 \001 \005\002\003\005\006\004.\001\005\012\002\001\017\012\002\011\006\017\007\010\001\006\011\023\007\010\007\004\017\002\001\005\012\002\015\022?=\026=\026 \026\026 ==&' \001 \023\026 \001 \002@\021\010\015\022\006\004.\001\017\010\007\006\011\003\001\015\025\001.\002\004\002\005\006\017\001\003\036\023\003\005\022\007\005\002\003=\026== \026\026 \026=&& \001 \017\026 \001 \005\012\002\001\002\025\025\006\017\007\017?\001\015\025\001\021\022\007\017\005\006\017\002=========\026== =\026\026 =&B \001 \013\026 \001 .\010\015\023\007\010\001\003\005\036\013\006\002\003\001\015\025\001\003\017\012\006\020\015\021\012\022\002\004\006\007\001\007\004\013\001\013\002\021\022\002\003\003\006\015\004 \001 \001 A' \001 \006C\026 \001 \002\003\003\002\004\005\006\007\010\006\003\011\001C\003\001 \021\015\021\036\010\007\005\006\015\004\001\005\012\006\004\016\006\004. ==\026\026\026 ==== =\026\026\026 AD \001 \007\026 \001 \003\005\007\005\006\003\005\006\017\007\010\001\011\002\017\012\007\004\006\017\003\001\007\004\013\001\005\012\002\001E\010\007\027\001\007\023\015\036\005\001 \002\022\022\015\022\003F=======================A \001 \023\026 \001 \002\003\003\002\004\005\006\007\010\006\003\011\001\007\004\013\001\005\007@\015\004\015\011?======== \026 ==\026\026\026 \026\026\026A \001 \017\026 \001 \012\002\007\010\005\012\030\001 \006\010\010\004\002\003\003 \030\001\007\004\013\001\025\006\005\004\002\003\003 == =======\026= =\026\026\026 \050' \001 \013\026 \001 \021\015\021\036\010\007\005\006\015\004\001\005\012\006\004\016\006\004.======== ===== \026\026 == \026\026 \050& \001 C\026 \001 \005\012\002\001\004\015\004 < \002\003\003\002\004\005\006 \007\010\006\003\005\001\023\022\007\006\004===\026 =======\026== \026\026 = \050D \001 \007\026 \001 \036\004\013\002\022\003\005\007\004\013\006\004.\001\005\012\002\001\023\022\007\006\004===========\026==\050 \001 \023\026 \001 \007\001\004\015\004 < \002\003\003\002\004\005\006\007\010\006\003\011\001\007\010\005\002\022\004\007\005\006C\002=======\026==\026B' \001

PAGE 5

\003 \002 \002 \017\026 \001 \003\012\006\020\015\021\012\022\002\004\006\007\030\001\013\002\021\022\002\003\003\006\015\004\030\001\007\004\013\001\021\015\021\036\010\007\005\006\015\004\001 \005\012\006\004\016\006\004.======================BA \001 \013\026 \001 \003\036\011\011\007\022?====================\026=\026\026D' \001 C\006\026 \001 \003\036\011\011\007\022?\001\007\004\013\001\017\015\004\017\010\036\003\006\015\004== ====== \026\026\026 =====\026\026 D& \001 C\006\006\026 \001 \027 \015\022\016\003\001\017\006\005\002\013=====================\026\026\026 DD \001 C\006\006\006\026 \001 \022\002\025 \002\022\002\004\017\002\003======================\026D \001

PAGE 6

\004 \002 \002 \006\015\001\016\004\011\005\007\017 \007 \017\014\004\005\012\020\021\006\004\017\012\014 \007 \005\034\031\001/\051\035/"\032\031\001"#\001\033\034 \032\001\033\034\031\032 \032\001 \032\001\033"\001-%\032\033\001,"\051*\033\001"\037\001%\001$"*%$\001%\032\032\051+/\033 "\037\001"#\001\031\032\032\031\037\033 %$ \032+\001 \033\034%\033\001\051\037,\031\035$ \031\032\001/%\033\034"$" -%$\001-%\033\031"\035 %\033 "\037\001 \037\001\033\034\031\001 /\032\024-\034"$" -%$\001,"\051+\031\037\033\001\037"\037\001%\032\001\033\034\031\001 \013 %\037"\032\033 -\001%\037,\001\003\033%\033 \032\033 -%$\001\011%\037\051%$\001"#\001\011\031\037\033%$\001\013 \032"\035,\031\035\032\001 \013\003\011 : \026\001\001 \005 \034 \032\001/\035\031 < -$%\032\032 # -%\033"\035\024\001 %\032\032\051+/\033 "\037\001 /\035\031\032\051+\031\032\001\033\034%\033\001%$$\001+\031\037\033%$\001-"\037, \033 "\037\032\001%\035\031\001\033\034\031\001\035\031\032\051$\033\001"#\001\031\032\032\031\037\033 %$ \032\033\001-%\051\032\031\032 \001 %\037,\001 \033\034\051\032\001/\035\031-$\051,\031\032 \001 %\037\024\001"\033\034\031\035\001/"\032\032 *$\031\001%//\035"%-\034\001\033"\001,\031\032-\035 \037\001\032\051-\034\001 /\034\031\037"+\031\037% \026\001\001\006\001%\035\051\031\001\033\034%\033\001 /\035"\035\031\032\032\001\033"%\035, \001 \033\034\031\001\051\037,\031\035\032\033%\037, \037\001%\037,\001\033\035\031%\033+\031\037\033\001"#\001-\031\035\033% \037\001+\031\037\033%$\001 $$\037\031\032\032\031\032\001\034%\032\001*\031\031\037\001 \032\033\024+ \031,\001#"\035\001\033\034 \032\001\035\031%\032"\037\026\001\001\006\037\001"\035,\031\035\001\033"\001-%\032\033\001,"\051*\033\001"\037\001\033\034 \032\001$"*%$\001%\032\032\051+/\033 "\037\030\001%$$\001\033\034%\033\001 \032\001 \037\031\031,\031,\001 \032\001\033"\001\051\037,\031\035+ \037\031\001\033\034\031\001 \051\037 !\031\035\032%$ \033\024\001-$% +\001 \037 \001 \033\034\031\001\013\003\011 \030\001 \034 -\034\001! \031\032\001+\031\037\033%$\001, \032"\035,\031\035\032 \001 %\032\001\031\032\032\031\037\033 %$ \032\033\001 \037, \032 \026\001\001\005"\001\033\034 \032\001\031\037,\030\001\006\001 $$\001#"-\051\032\001"\037\001\033"\001+\031\037\033%$\001-"\037, \033 "\037\032\030\001\032-\034 "/\034\035\031\037 %\001 %\037,\001,\031/\035\031\032\032 "\037\026\001\001 \005\034\031\001 %\035\051+\031\037\033\001 $$\001*\031\001+%,\031\001 %\032\001#"$$"\032\026 \001 \001 \027\034\031\037\001, \032-\051\032\032 \037\001 ,\031%\032\001"#\001E\034\031%$\033\034 \030F\001\033\034\031\035\031\001 \032 \001 %\037\001 %\032\032\051+/\033 "\037\001\033\034%\033\001 E\034\031%$\033\034\024F\001 \032\033%\033\031 \032 \001 % \035\031\001 \033\034"\032\031 \001 \034\031\035\031\001\033\034\031\001"/\031\035%\033 "\037 %$ \001 /\035"-\031\032\032\031\032\001"#\001%\037\001 \037, ,\051%$\001%\035\031\001#\051\037-\033 "\037 \037\001E\037"\035+%$$\024\026F\001\001\005\034 \032\001 +/$ \031\032 \001 \033\034%\033\001\032\033%\033\031\032\001"#\001 E $$\037\031\032\032 F \001 \035\031#$\031-\033 \001 \032"+\031\001 %*\037"\035+%$ \033\024\001"\035\001,\024\032#\051\037-\033 "\037 \001 \037\001\033\034\031\032\031\001 /\035"-\031\032\032\031\032\026\001\001 \003\051-\034\001%\032\032\051+/\033 "\037\032\001\033\034\031\037\001, ,\031\001 ,\031%\032\001"#\001E\034\031%$\033\034F\001%\037,\001E\037"\037 < \034\031%$\033\034F\001*\031\033\031\031 \037\001/\035"-\031\032\032\031\032\001\033\034%\033\001 %\035\031\001\037"\035+%$\001%\037,\001\033\034"\032\031\001\033\034%\033\001%\035\031\001\033\034\031\001\035\031\032\051$\033\001"#\001%\001, \032\033\051\035*%\037-\031\001\033"\001\033\034 \032\001\037"\035+%$\001#\051\037-\033 "\037\026\001\001 \005\034 \032\001 \031\001 \032\001\031\032\032\031\037\033 %$ \032\033 \026\001\001 \002\032\032\031\037\033 %$ \032+\001 \032\001%\037\001\031;/$%\037%\033"\035\024\001\032\033\035%\033\031\024\001\034\031\035\031 \037\001\033\024/\031\032\001%\035\031\001,\031\032-\035 *\031,\001 %\037,\001-%\033\031"\035 \031,\001*\024\001+\031%\037\032\001"#\001 ,\031\037\033 # \031,\001+\031-\034%\037 \032+\032\001"\035\001/\035"/\031\035 \033 \031\032\026\001\001\005\034\031\032\031\001/\035"/\031\035\033 \031\032\001%\035\031\001 \033\034\031\001-"\037\032\033 \033 \051\031\037\033\001-"\037, \033 "\037\032\001 \033\034%\033\001\031;/$% \037\001\034\024\001%\001\033\024/\031\001"\035\001-%\033\031"\035\024\001 \032\001\033\034\031\001%\024\001 \033\001 \032\026\001\001 \005\034 \032\001 \031;/$%\037%\033 "\037\001"#\001/\034\031\037"+\031\037%\001%\032\032\051+\031\032\001\033\034%\033\001%\037\024\001,\031! %\033 "\037\001#\035"+\001\033\034\031\001\033\024/\031\001\035\031#$\031-\033\032\001\032"+\031\001 \037\033\031\035#\031\035\031\037-\031\001"\035\001+%$#\051\037-\033 "\037\001"#\001\033\034\031\001\051\037,\031\035$\024 \037\001-%\051\032%$\001+\031-\034%\037 \032 +\032\026 \001\001 \001

PAGE 7

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\012 \002 \002 \017$ \037 -%$\001\033\034\031\035%/\031\051\033 -\001%//\035"%-\034\031\032\001 #"\035\001\033\034\031\032\031\001-"\037, \033 "\037\032\001 \035\031#$\031-\033\001%\037,\001%\035\031\001,\031\035 !\031,\001 #\035"+ \001 \033\034 \032\001/%\035%, +\026\001 \001 \006#\001\033\034\031\035%/\031\051\033 -\001+",\031$\032\001%\035\031\001\037"\033\001\031##\031-\033 !\031\001 \037\001 \033\034\031\001\033\035\031%\033+\031\037\033\001"#\001 \032 -\034 "/\034\035\031\037 %\001 %\037,\001,\031/\035\031\032\032 "\037 \030\001\033\034\031\037\001\033\034\031\001%--\051\035%-\024\001%\037,\001%//\035"/\035 %\033\031\037\031\032\032\001"#\001\033\034\031\032\031\001, %\037"\032\033 -\001,\031# \037 \033 "\037\032\001 *\031-"+\031\032\001\032\051\032/\031-\033 \026\001 \027 \031\001%\035\031\001 \033\034\031\037\001 $ \031#\033\001 \033\034\001\033\034\035\031\031\001/"\032\032 $ \033 \031\032\001 \033"\001%--"\051\037\033\001#"\035\001\033\034 \032 \026\001\001\025 \035\032\033\030\001\033\034\031\001 -"\035\035\031-\033\001+\031-\034%\037 \032+\001\034%\032\001\024\031\033\001\033"\001*\031\001 ,\031\037\033 # \031,\001%\037,\001#\051\035\033\034\031\035\001 \037!\031\032\033 %\033 "\037\001 \032\001\035\031\000 \035\031,\026\001\001\003\031-"\037,\030\001 +\051$\033 /$\031\001-"\037, \033 "\037\032\001\034%!\031\001*\031\031\037\001-"\037#$%\033\031,\001 \037\033"\001"\037\031\030\001\031%-\034\001 \033\034\001 %\001 /"\032\032 *$\031\001+\051$\033 /$ \033\024\001"#\001 -%\051\032%$\001+\031-\034%\037 \032+ \032\026\001\001\007\037,\001$%\032\033$\024\030\001 \033\034\031\001-"\037, \033 "\037\032\001"#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\001,"\001\037"\033\001 \031; \032\033\001 \037\001\033\034\031\001%\024\001\033\034%\033\001\033\034\031\024\001%\035\031\001,\031\032-\035 *\031,\001 \037\001\033\034\031\001\013\003\011\026\001\001\006#\001\033\034\031\001$% \032\033\001/"\032\032 $ \033\024\001 \032\001\033\035\051\031\030\001\033\034\031\037\001%\001 \037"\037 < \031\032\032\031\037\033 %$ \032\033\001 %$\033\031\035\037%\033 !\031\001+\051\032\033 \001 *\031\001/\035"/"\032\031,\026\001\001 \001 \005\034\035"\051\034\001\033\034\031\001%//\035"%-\034\001"#\001/"/\051$%\033 "\037\001 \033\034 \037 \037 \030\001+",\031$\032\001%\037\001*\031\001\031\037\031\035%\033\031,\001\033\034%\033\001+%\024\001 /\035"! 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\013 \002 \002 \033\034\001\035\031%\035,\001\033"\001\033\034\031\001+\031\037\033%$\001-"\037, \033 "\037\032\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037 \026\001\006 \037\001\017\034%/\033\031\035\001\006\006\006 \030\001"\051\035\001 \032-\051\032\032 "\037\001 $$\001\033\051\035\037\001\033"\001 % \037\001%\037%$\024\032 \032\001%\037,\001 -\035 \033 \000\031\001"#\001 \033\034\031\001 -"\037\033\031+/"\035%\035\024\001 +\031\034%\037 \032\033 -\001 \033\034\031"\035 \031\032 \001 "##\031\035\031,\001 #"\035 \001 \033\034\031\001\031\032\032\031\037\033 %$ \032\033 \001 \051\037,\031\035\032\033%\037, \037\001"#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037 \026\001 \001 \005 \034\035"\051\034\001 -\051\035\035\031\037\033\001\035\031\032\031%\035-\034 \001 %\037,\001\032\033%\033 \032\033 -%$\001\032\033\051, \031\032 \030 \001 \000\031\032\033 "\037\032 \001 $$\001*\031\001 \035% \032\031,\001%*"\051\033 \001 \033\034\031\001$"*%$ \031, \001 %\032\032\051+/\033 "\037\001"#\001\033\034 \032\001\031\032\032\031\037\033 %$ \032\033\001%//\035"%-\034 \026\001 \001 \006\037\001\017\034%/\033\031\035\001\006C\030\001 \033\034\031\001$ + \033%\033 "\037\032\001\033\034%\033\001%\037\001 \031\032\032\031\037\033 %$ \032\033\001\032\033\035%\033\031\024\001\034%\032\001/"\032\031,\001#"\035\001"\033\034\031\035\001\032\031\037-\031\032\001\032\051-\034\001%\032\001* "$"\024\001%\037,\001\032\033%\033 \032\033 -%$\001+\031-\034%\037 -\032\001 $$\001*\031\001/\035\031\032\031\037\033\031,\026\001\001 \025 \037%$$\024\030\001 %\037\001%$\033\031\035\037%\033\031\030\001\037"\037 < \031\032\032\031\037\033 %$ \032\033\001%//\035"%-\034 \001 $$\001*\031\001 "##\031\035\031, \001 \033\034\035"\051\034\001 \033\034\031 \001 \032\033\035%\033\031\024\001"#\001/"/\051$%\033 "\037\001 \033\034 \037 \037 \001 "\037\001\033\034\031\001+\031\035 \033\032\001"#\001 -\031\035\033% \037\001%,!%\037\033%\031\032\001\033\034%\033\001\033\034 \032\001%//\035"%-\034\001 \034%\032\001"##\031\035\031,\001#"\035 \001 # \031$, \032\001\032\051-\034\001%\032\001\031!"$\051\033 "\037%\035\024\001* "$"\024\026\001\001\027 \033\034\001\033\034\031\001\033\034\031"\035\031\033 -%$\001#"\051\037,%\033 "\037\001#"\035\001%\001 \037"\037 < \031\032\032\031\037\033 %$ \032\033\001%$\033\031\035\037%\033 !\031\001,\031\032-\035 *\031,\030\001\017\034%/\033\031\035\001C\001 $$\001 ,\031\032-\035 *\031 \030\001# \035\032\033\030 \001 %\001\037"\037 < \031\032\032\031\037\033 %$ \032\033\001 %//\035"%-\034\001\033"\001\051\037,\031\035\032\033%\037, \037\001\033\034\031\001*\035% \037 \026\001\001\007\001+",\031$\001 $$\001*\031\001/\035"/"\032\031,\001 \033\034%\033 \001 ,\031\032-\035 *\031 \032 \001 \033\034\031\001 \032\024\032\033\031+ \032\001"#\001\033\034\031\001*\035% \037\001%\032 \001 \037\033\031\035\035\031$%\033 "\037%$ \001 %\037,\001%,%/\033 !\031\001/"/\051$%\033 "\037 \032 \001 "#\001\037\031\051\035 %$\001 \032 \037%$ \037\001 -"\037\037\031-\033 "\037\032 \026\001\001\005\034\031\001! \035\033\051\031\032\001"#\001\033\034 \032\001%//\035"%-\034\001 $$\001\033\034\031\037\001*\031\001\031;/$"\035\031,\001 \033\034\001\035\031%\035,\001\033"\001 \051\037,\031\035\032\033%\037, \037\001\033\034\031\001+\031\037\033%$\001-"\037, \033 "\037\032\001"#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037 \026 \001\001 \015\037\001\033\034\031\001*%\032 \032\001"#\001 \033\034 \032\001#"\051\037,%\033 "\037\030\001%\001#\051\035\033\034\031\035\001/"/\051$%\033 "\037 \032\033\001+",\031$\001 $$\001*\031\001/\035\031\032\031\037\033\031,\001#"\035\001 \037!\031\032\033 %\033 \037\001\033\034\031\001 /\034\031\037"+\031\037%\001"#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\001 "\037\001\033\034\031\001+%-\035"\032-"/ -\001$\031!\031$ \001 "#\001 \033\034\031\001$%\035\031\035\001 \034\051+%\037\001/"/\051$%\033 "\037\026\001\001 \027 \033\034\001\033\034\031\001%$\033\031\035\037%\033 !\031\001 /\035\031\032\031\037 \033\031, \030\001%\001-%\032\031\001 $$\001*\031\001+%,\031\001#"\035\001\034"\001\032\051-\034\001%\037\001 %$\033\031\035\037%\033 !\031\001-"\051$,\001\051\037,\031\035+ \037\031\001-"\037# ,\031\037-\031\001 \037\001\033\034\031\001\033\035%, \033 "\037%$\001\051\037,\031\035\032\033%\037, \037\001"#\001\033\034\031\032\031\001 -"\037, \033 "\037\032\001%\037,\001,"\051*\033\001-%\032\033\001"\037\001\033\034\031\001$"*%$\001%\032\032\051+/\033 "\037\001"#\001\031\032\032\031\037\033 %$ \032+\001 \033\034\001\035\031%\035,\001\033"\001 /%\033\034"$" -%$\001-%\033\031"\035 \031\032\001 \037\001\033\034\031\001\013\003\011\026\001\001

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PAGE 15

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PAGE 18

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PAGE 24

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PAGE 25

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PAGE 27

\005\005 \002 \002 \033\034\031\032\031\001-$% +\032\030\001/\035",\051\037 \001 \033\034\031\001\032%+\031\001\035\031\032\051$\033\032\001%\032\001*\031#"\035\031\026\001\001\006\037\001&''A\030\001%#\033\031\035\001"\035 \037\001#"\035\001\024\031%\035\032\001 \032\033\051,\024 \037\001*\035% \037\001\032\031\035"\033"\037 \037\001+\031\033%*"$ \032+\030\001\023\051\035\037\032\001-"\037-$\051,\031,\001\033\034%\033\001\034\031\001E\037\031!\031\035\001\032%\001-"\037! \037\037\001 \031! ,\031\037-\031\001\033\034%\033\001%\037\024\001/\032 \024-\034 %\033\035 -\001, \032"\035,\031\035\001 \037-$\051, \037\001,\031/\035\031\032\032 "\037\001\035\031\032\051$\033\032\001#\035"+\001%\001,\031# \031\037-\024\001"#\001 *\035% \037\001\032\031\035"\033"\037 \037\026 F A \001 \001 \003 + $%\035$\024\030\001,"/%+ \037\031\001\034%\032\001$"\037\001*\031\031\037\001\033\034\031\001\037\031\051\035"\033\035%\037\032+ \033\033\031\035\001%\032\032"%\033\031,\001 \033\034\001\033\034\031\001 \032"\035,\031\035\001"#\001\032-\034 "/\034\035\031\037 %\026\001\001 \005\034\031\001\033\034\031"\035\024\001/\051\035/"\035\033\032 \001 \033\034%\033\001 +*%$%\037-\031\032\001-"\037\033\035 *\051\033 \037\001\033"\001 \032-\034 "/\034\035\031\037 %\001\032/\031# -%$$\024\001 \037!"$!\031\001\033\034\031\001\013 \001 %\037,\001\013 & \001 ,"/%+ \037\031\001\035\031-\031/\033"\035\032\026\001\001\003 \037-\031\001 -\031\035\031*\035"\032/ \037%$\001\012C\007\001$\031!\031$\032\001/\035"!\031,\001\033"\001*\031\001\037"\035+%$\001 \037\001\051\037+\031, -%\033\031,\001\032-\034 "/\034\035\031\037 -\032\001%\032\001 -"+/%\035\031,\001\033"\001-"\037\033\035"$\001\035"\051/\032\030\001\033\034\031\001\033\034\031"\035\024\001%\035"\032\031\001\033\034%\033\001/\031\035\034%/\032\001/%\033 \031\037\033\032\001\034%,\001%\037\001"!\031\035%*\051\037,%\037-\031\001 "#\001\033\034"\032\031\001,"/%+ \037\031\001\035\031-\031/\033"\035 \032\026\001\001\007\051\033"/\032\024\001%\037,\001*\035% \037\001\032-%\037\001\032\033\051, \031\032\001\033\034\035"\051\034\001\033\034\031\001>'G\032\001 \037,\031\031,\001 \035\031!\031%$\031,\001%\001/\035"$ #\031\035%\033 "\037\001"#\001\013 & \001 \035\031-\031/\033"\035\032\001 \037\001/%\033 \031\037\033\032\001, %\037"\032\031,\001 \033\034\001\032-\034 "/\034\035\031\037 %\026\001\001\005\034\031\001 /\035"*$\031+\001%\032\030\001\034"\031!\031\035\030\001\033\034%\033\001\033\034 \032\001%\032\001"\037$\024\001\033\034\031\001-%\032\031\001 \037\001\033\034\031\001*\035% \037\032\001"#\001\033\034" \032\031\001 \033\035\031%\033\031,\001 \033\034\001 \037\031\051\035"$\031/\033 -\032\026\001\001\036 \037+\031, -%\033\031,\001 \037, ,\051%$\032\001 \033\034\001\032-\034 "/\034\035\031\037 %\001\032\034"\031,\001E\037"\001\035\031/"\035\033\031,\001 ##\031\035\031\037-\031\032F\001 \033\034 \001 \035\031%\035,\001\033"\001%*\037"\035+%$\001\013 & \001 \035\031-\031/\033"\035\032\001\034\031\037\001-"+/%\035\031,\001 \033\034\001E\037"\035+%$F\001 -"\037\033\035"$\032\026 \050 \001\001 \025 "\035+\031\035\001, \035\031-\033"\035\001"#\001\004\006\011\012\001\003\033\031!\031\001\012\024+%\037\001\031;/$% \037\032\001\033\034%\033\001 \033\034\031\001\035\031%\032"\037\001#"\035\001\033\034 \032\001 \032\001\033\034%\033\001 %$$\001/\032\024-\034"\033\035"/ -\001,\035\051\032 \030\001 \037\001#%-\033 \030 \001 /\031\035\033\051\035*\001 \033\034\031\001 \037"\035+%$ \001 #\051\037-\033 "\037\001"#\001\037\031\051\035"\033\035%\037\032+ \033\033\031\035\032\026\001\001 \017"\037# \035+\031, \001 *\024\001"!\031\035\001A'\001\024\031%\035\032\001"#\001\035\031\032\031%\035-\034\030\001\012\024+%\037\001%\035\051\031\032\001\033\034%\033\001\037"\033\001"\037$\024\001 -%\037 \001 \033\034 \031\001-\034\031+ -%$\001 +*%$%\037-\031\001\033\034\031"\035\024\001*\031 \001 H\051,\031,\001#%$\032\031K \001 \033\001\034%\032\001 +"\035\031"!\031\035\001 *\031-"+\031\001-$\031%\035\001\033\034%\033\001 \033\001 \032\001"\037$\024\001%#\033\031\035\001 \031;/"\032\051\035\031\001\033"\001+\031, -%\033 "\037\032\001\033\034%\033\001%\001-\034\031 + -%$\001 +*%$%\037-\031\001\031!\031\035\001-"+\031\032\001\033"\001\031; \032\033\026 \001 \013\030\031\017\005\004\011\002\025\012\010\017\016\011\020\014\012\005\027\012"\015\002\015\003\011\010\012\024\007\032\014\003\004\016\003\015\014 \012 \001 \005 \034\031\001 /\035\031! 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PAGE 28

\005\006 \002 \002 +"\037"\024"\033 -\001\033 \037\032\001\034\031\035\031\001''M\001"#\001\033\034\031\001\031\037\031\033 -\001+%\033\031\035 %$\001 \032\001\032\034%\035\031,\001%\032\001-"+/%\035\031,\001\033"\001 \024"\033 -\001\033 \037\032\001\033\034%\033\001\032\034%\035\031\001"\037$\024\001B'M\001$ \031\001\033\024/ -%$\001\032 *$ \037\032\026\001\001\015#\001\033\034\031\032\031\001\035"\051/\032\030\001\033\034\031\001\035 \032\001#"\035\001 +"\037"\024"\033 -\001\033 \037\032\001 \035%\037\031,\001#\035"+\001\050' < B'M\030\001\034\031\035\031\001%\032\001\033\034\031\001\035 \032\001\033\034%\033\001*"\033\034\001, \024"\033 -\001\033 \037\032\001 "\051$,\001,\031!\031$"/\001\033\034\031\001-"\037, \033 "\037\001%\032\001"\037$\024\001' < BM\026 B \001 \002\000%$$\024\030\001\033\034\031\001\035 \032\001%//\031%\035\032\001\033"\001*\031\001+\051-\034\001 \034 \034\031\035\001#"\035\001-\034 $,\035\031\037\001"#\001/%\035\031\037\033\032\001 \033\034\001\032-\034 "/\034\035\031\037 %\001\033\034%\033\001\031\035\031\001%,"/\033\031,\001*\024\001\037"\037 < \032-\034 "/\034\035\031\037 -\001 /%\035\031\037\033\032\001\033\034%\037\001#"\035\001-\034 $,\035\031\037\001 \034\031\035\031\001\033\034\031\001-%\032\031\001 \032\001\035\031!\031\035\032\031, \026\001\001 \023\024\001&''\030\001%\001+\031\033% < %\037%$\024\032 \032\001\034%,\001*\031\031\037\001 -"+/ $\031,\001*\024\001\005%\037,"\037\001\031\033\001%$ \026 \001 "#\001+\051-\034\001"#\001\033\034\031\001\035\031\032\031%\035-\034\001 \033\034%\033\001#"$$"\031,\001\033\034"\032\031\001\031%\035$ \031\035\001\032\033\051, \031\032\001 \037\033" \001 \033\034\031\001\031\037\031\033 -\001%\037,\001,\031!\031$"/+\031\037\033%$\001\031$\031+\031\037\033\032\001"#\001 \033\034\031 \001 -"\037, \033 "\037 \026\001\001\006\037\001\033\034\031\001%\035\033 -$\031\001E\003-\034 "/\034\035\031\037 %\030\001 NO\051\032\033\001\033 \034\031\001\025%-\033\032G\001\027\034%\033\001\031\001\037"\001 \037\001&''\030F\001\033\034\031\001\035\031\032\031%\035-\034\001 \037\033"\001-"\037\033\035 *\051\033 \037\001#%-\033"\035\032\001#"\035\001 \032-\034 "/\034\035\031\037 %\001%\032\001\035\031! 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\005\013 \002 \002 +\031+"\035\024\030\001$"\032\032\001"#\001-\035\031%\033 \033\024\030\001*$\051\037\033\031,\001%##\031-\033\030\001#%\033 \051\031\030\001%\037,\001$\031%\035\037 \037\001,\031# \031\037\031\032\026 \001\001 \003\051-\034\001 \032\024+/\033"+\032\001"\037$\024\001\032 \031\035!\031\001\033"\001\031;%-\031\035*%\033\031\001\033\034\031\001-"\037, \033 "\037\001#"\035\001\034 -\034\001\033\034\031\032\031\001,\035\051\032\001%\035\031\001/\035\031\032-\035 *\031,\030\001 \035\031-\033$\024\001 +/% \035 \037\001\033\034\031\001 \037, ,\051%$G\032\001-%/%\033\024\001\033"\001$\031%\035\037\001\034"\001\033"\001-"/\031\001 \033\034\001, \032\033\035\031\032\032 \037\001 \031+"\033 "\037\032\001%\037,\001\035\031-"!\031\035\001#\035"+\001\032\051-\034\001, \032\033\035\031\032\032\026 \001\001 \013 \032-"!\031\035 \031\032\001\032\051-\034\001%\032\001\033\034\031\032\031\001\035\031!\031%$\001#\051\035\033\034\031\035\001 +/$ -%\033 "\037\032\001#"\035\001\033\034 \031\001\031\032\032\031\037\033 %$ \032\033\001\032\033\035%\033\031\024\001%\032\001\032\051-\034\001/\035%-\033 -\031\032\001#"$$"\001, \035\031-\033$\024\001#\035"+\001\033\034 \032\001 \033\034\031"\035\031\033 -%$\001#"\051\037,%\033 "\037K\001\037%+\031$\024\001\033\034\031\001*\031$ \031#\001\033\034%\033\001\033\034\031\001/\051\035/"\032\031\001"#\001-$ \037 -%$\001 \037\033\031\035!\031\037\033 "\037\001 \032\001\033"\001 \033\035\031%\033\001,\031! 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\006\005 \002 \002 "#\001\034\031\033\034\031\035\001\033\034\031\035\031\001+ \034\033\001*\031\001%\001, ##\031\035\031\037-\031\001*\031\033\031\031\037\001+\031, -%\033\031,\001%\037,\001\051\037+\031, -%\033\031,\001,\031/\035\031\032\032 "\037\001 %\032\001/"\032\031,\026\001\001\011 -\034%\031$\001\021"\032\033\031\035\037%\001 ,\031\037\033 # \031,\001\050\001/%\033 \031\037\033\032\001 \037\001\004\006\011\012G\032\001\021\032\024-\034"* "$"\024\001"#\001 \013\031/\035\031\032\032 "\037\001/\035"\035%+\001\034"\001\034%,\001\035\031$%/\032\031,\001#"$$" \037\001\033\034\031\001\031\032\032%\033 "\037\001"#\001%\037\033 ,\031/\035\031\032\032%\037\033\001 \033\035\031%\033+\031\037\033\030\001*\051\033\001\034%,\001\037"\033\001\035\031\032\051+\031,\001\033% \037\001+\031, -%\033 "\037\026\001\001E&AM\001\035\031-"!\031\035\031,\001 \037\001"\037\031\001+"\037\033\034\030F\001 %--"\035, \037\001\033"\001\021"\032\033\031\035\037%\030\001EDM\001 \037\001\032 ;\001+"\037\033\034\032\030\001%\037,\001BM\001 \033\034 \037\001%\001\024\031%\035\026F\001\001\005\034 \032\001-"\037# \035+\031,\001 \033\034\031 \001 \037 \033 %$\001/\035"\037"\032 \032\001 "#\001/\032\024-\034 %\033\035 \032\033\001\002+ $\001\016\035%\031/\031$ \037\001 #\035"+\001''\001\024\031 %\035\032\001/\035 "\035\001\033\034%\033\001\051\037\033\035\031%\033\031,\001 ,\031/\035\031\032\032 !\031\001\031/ \032",\031\032\001"#\033 \031\037\001\035\031\032"$!\031\001\033\034\031+\032\031$!\031\032\001 \033\034 \037\001D\001 < \001 \001 +"\037\033\034\032\026 & \001 \001 \006\037\001\035\031%\035,\001\033"\001\032-\034 "/\034\035\031\037 %\030\001%\001+\031\033% < %\037%$\024\032 \032\001%\032\001-"+/ $\031,\001*\024\001. 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\007\005 \002 \002 \035\031-"+* \037%\033 "\037\032\001 /"\032\032 *$\031\001 \033\034\035"\051\034\001\032\031;\051%$\001\032\031$\031-\033 "\037 \030 \001 %\032\001\031$$\001%\032\001/\034\031\037"\033\024/ -\001\031;/\035\031\032\032 "\037\032\001 \033\034%\033\001 -%\037\001\031+\031\035\031\001 \037\001\035\031\032/"\037\032\031\001\033"\001 % \001 !\031\037\001\031\037! \035"\037+\031\037\033\026\001\001\005"\001,\031# \037\031\001+\031+*\031\035\032\001"#\001%\001\035"\051/\001"\035\001\032\033%\033\031\032\001 "#\001\034\031%$\033\034\001 \037\001\032\051-\034\001\035\031\032\033\035 -\033 !\031\001\033\031\035+\032\001\032\031\031+\032\001/\035" *$\031+%\033 -\030\001\033"\001\032%\024\001\033\034\031\001$\031%\032\033\026\001\001\006\037\001#%-\033\030\001 !\031\037\001\033\034\031\001 ++\031\037\032 \033\024\001"#\001\032\051-\034\001/"\032\032 $ \033\024\030\001"\037\031\001+ \034\033\001\031;/\031-\033\001\033"\001\032\031\031\001\031!\031\037\001\035\031%\033\031\035\001, !\031\035\032 \033\024\001\033\034%\037\001 \032\001 "*\032\031\035!\031,\001 \037\001\037%\033\051\035\031\026\001\001\027\034%\033\001 \032\001, \032-"!\031\035\031,\030\001\034"\031!\031\035\030\001 \032\001\033\034%\033\001 \035%\037\031\032\001"#\001 *"\033\034\001\031\037"\033\024/\031\032\001%\037,\001 /\034\031\037"\033\024/\031\032\001%\035\031\001, \032\033\035 *\051\033\031,\001%-\035"\032\032\001\033 \034\031\032\031\001\035"\051/ \037 \032 \001 \037"\035+%\033 !\031$\024\030\001%\032\001\035\031/\035\031\032\031\037\033\031,\001 "\037\001% \001 *\031$$\001 -\051\035!\031\026\001\001\005\034 \032\001 \032\001\034%\033\001 \032\001\033\031\035+\031, \001 \033\034\031 \001 E\037"\035+\001"#\001\035\031%-\033 "\037KF\001%\001+\031%\037\032\001*\024\001\034 -\034\001 ##\031\035\031\037\033\001\031\037\031\033 -\001 \035\031\032\051$\033\032\001 -%\037\001*\031\001+\031%\032\051\035\031,\001%\037,\001,\031/ -\033\031,\001%\032\001\033\034\031\024 \001 \031+\031\035\031\001 \037\001, ##\031\035 \037\001\031\037! 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\007\006 \002 \002 %-\035"\032\032\001%\001/"/\051$%\033 "\037\001"#\001%\001-\031\035\033% \037\001 \037,\026 & \001\001 \027\034\031\035\031 \001 \033\034\031\001/"/\051$%\033 "\037 \001 \032\001\032\031\033\001%\032\001\033\034\031\001#"-\051\032\001 %*"!\031 \001 \033\034\031\001 \037, ,\051%$ \030\001 #%-\033"\035\032\001\033\034%\033\001 \037#$\051\031\037-\031\001\033\034\031\001\032\033\035\051-\033\051\035\031\001"#\001\033\034 \032 \001 !\031\035\032 \033\024\001%\035\031\001"#\001-\031\037\033\035%$\001-"\037-\031\035 \037 \030\001 \035%\033\034\031\035\001\033\034%\037\001\051\037 #"\035+ \033\024\001\034\031\035\031\001\034"+\031"\032\033%\032 \032\001 \032\001+ \032\033%\031\037 $\024\001/\035\031\032\051+\031,\001%\032\001\033\034\031\001\037"\035+ \026 && \001\001 \006\033\001 \032\001\037"\033\001 %\001+%\033\033\031\035\001"#\001# \037, \037\001\033\034\031\001\032 + $%\035 \033\024\001"#\001%\001/\035"/" \032\031,\001\051\037,\031\035$\024 \037\001 \035\031%$ \033\024\001%+ ,\032\033\001, !\031\035\032 \033\024 \030\001*\051\033\001 \033\034\031\001\035\031%$ \033\024\001\033\034%\033\001 \032\001\032\051\032\033% \037\031,\001*\024\001, !\031\035\032 \033\024 \026\001\001\003 \037-\031\001\033\034\031\001+\031+*\031\035\032\001"#\001%\001/"/\051$%\033 "\037\001%\035\031\001\033%\031\037\001\033"\001 *\031\001\051\037 \000\031 \030\001\032\034%\035\031,\001\032 + $%\035 \033 \031\032\001%\035\031\001! 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\007\010 \002 \002 %\035\031\001+"\035\031\001%//\035"/\035 %\033\031\001#"\035\001,\031\032-\035 \037\001\032"+\031\001/\034\031\037"+\031\037%\001 \037\001\037%\033\051\035\031\026\001\001\027\034%\033\001 \032\001+"\032\033\001 +/"\035\033%\037\033\001 \032\001\033\034\031\001\031;/$%\037%\033"\035\024\001!%$\051\031\001"#\001\033\034\031\001\032\033\035%\033\031\024\026\001\001\027\034 -\034\001\031;/$%\037%\033 "\037\001\033\031$$\032\001\033\034\031\001*\031\032\033\001\032\033"\035\024P\001\001\027\034 -\034\001 %//\035"%-\034\001$\031%,\032\001\033"\001\035\031%\033\031\035\001$\031!\031$\032\001"#\001 \037\000 \035\024 P\001\001\025"$$" \037\001\033\034\031\001/\035 \037/$\031\001"#\001/%\035\032 +"\037\024\030\001 \034 -\034\031!\031\035\001\032\033\035%\033\031\024\001/\035"! ,\031\032\001%\001+"\035\031\001 \037-$\051\032 !\031\001%--"\051\037\033\001#"\035\001\033\034\031\001/\034\031\037"+\031\037%\001 \037\001\000\031\032\033 "\037\001 \032\001 \033\034\031\001\032\033\035%\033\031\024\001\033\034%\033\001\032\034"\051$,\001*\031\001 !\031\037\001/\035\031#\031\035\031\037-\031\026 \001 \001 \005"\001 \033\034 \032\001/" \037\033\030\001\031\001\034%!\031\001\032\031\031\037\001\034"\001\031\032\032\031\037\033 %$ \032+\001\034%\032\001 \037#$\051\031\037-\031,\001\033\034\031\001\051\037,\031\035\032\033%\037, \037\001 %\037,\001 \033\035\031%\033+\031\037\033\001"#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\001 \037 \001 \033\034\031\001\013\003\011\026\001\001 \003\051\032/ "\037\032\001\034%!\031\001*\031\031\037\001\035% \032\031,\001 \033\034\001\035\031%\035,\001\033"\001\033 \034\031\001 !%$ \033\024\001"#\001\033 \034"\032\031\001\031;/$%\037%\033 "\037\032\001 \033\034\035"\051\034\001\033\034\031\001\033%\033 "\037\001"#\001\037\051+\031\035"\051\032\001-$ \037 -%$\001 \032\033\051, \031\032\001 %\037,\001\032\051\032/ "\037\032\001\035% \032\031, \001 %\032\001\033"\001\033\034\031\001%//\035"/\035 %\033\031\037\031\032\032\001"#\001\033\034\031\001\031\032\032\031\037\033 %$ \032\033\001\032\033\035%\033 \031\024\001 \037\001\033\034 \032\001 -"\037\033\031;\033 \026 \001\001 \011"\035\031"!\031\035\030\001#\051\037,%+\031\037\033%$\001/\035"*$\031+ \032\001\034%!\031\001*\031\031\037\001\031;/"\032\031,\001\034\031\037\001\033\034 \032\001\032\033\035%\033\031\024\001 \032\001 %//$ \031,\001$"*%$$\024\001\033"\001/%\035\033 -\051$%\035\001# \031$,\032\001"#\001\032\031\037-\031\001,\051\031\001\033"\001$ + \033%\033 "\037\032 \001 \034\031\037 \001 %--"\051\037\033 \037\001#"\035\001 !%\035 %\037-\031\001 #"\051\037,\001 \037\001%\001\035%\037\031\001"#\001/\034\031\037"+\031\037% \026\001\001\010%\032\033$\024\030\001%\001\037"\037 < \031\032\032\031\037\033 %$ \032\033\001%$\033\031\035\037% \033 !\031\001\033\034\035"\051\034\001 /"/\051$%\033 "\037\001\033\034 \037 \037\001\034%\032\001*\031\031\037\001/\035\031\032\031\037\033\031,\001 \033\034%\033\001\034%\032\001\032 \037-\031\001+%,\031\001\031\032\032\031\037\033 %$ \032\033\001\032\033\035%\033\031 \031\032\001 \051\037\037\031-\031\032\032%\035\024 \001 \033\034\001 \035\031%\035,\001\033"\001\033\034\031\001\032\033\051,\024\001 "#\001 -\031\035\033% \037\001$ \037\001 \032\024\032\033\031+\032\026 & \001\001 \027 \033\034\001\033\034\031\001\035"\051\037,"\035\001 $% ,\030\001\031\001-%\037\001\037"\001 \031;/$"\035\031\001\034%\033\001 \037\032 \034\033\032 \001 %\001\037"\037 < \031\032\032\031\037\033 %$ \032\033\001 %$\033\031\035\037%\033 !\031\001+ \034 \033\001/\035"! ,\031\001#"\035 \001 "\051\035\001\051\037,\031\035\032\033%\037, \037\001"#\001+\031\037\033%$\001-"\037, \033 "\037\032\030\001\032\051-\034\001%\032\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\026

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\007\011 \002 \002 \006\015\001\016\004\011\005 \007 \024 \007 \004\015\011\007\014\012\014 \027 \011\003\003\011\014\004\017\001\010\017\003\004\007\002\005\001\017\014 \007 \001 \025\035"+\001\033\034\031\001/\035\031! "\051\032\001-\034%/\033\031\035\032\030\001\031\001\034%!\031\001 #"\051\037,\001 *"\033\034\001\033\034\031"\035\031\033 -%$\001%\037,\001/\035%-\033 -%$\001\035\031%\032"\037\032\001 \033"\001*\031\001\032\051\032/ "\051\032\001"#\001%\001$"*%$ \031,\001%\032\032\051+/\033 "\037\001" #\001\031\032\032\031\037\033 %$ \032+\001%\032\001\033\034\031\001*\031\032\033\001%\024\001\033"\001\031;/$% \037\001 "*\032\031\035!%\033 "\037\032\001 \037\001+\031\037\033%$\001/%\033\034"$"\024 \026\001\001\005\034 \032\001 ,"\031\032\001\037"\033\001+\031%\037 \030\001\034"\031!\031\035\030 \001 \033\034%\033\001\033\034\031\035\031\001 %\035\031 \001 \037"\033\001 \031\032\032\031\037\033 %$ \032\033\001%\037\032\031\035 \032 \001 \033\034%\033\001-"\051$,\001*\031\001, \032-"!\031\035\031, \001 #"\035\001\032\051-\034\001-"\037, \033 "\037\032 \026\001 \001 \027\034%\033\001\033\034\031\037\001 + \034\033\001 \037-$ \037\031\001\051\032\001\033"\001%*%\037,"\037\001\032\051-\034\001$ \037\031\032\001"#\001\033\034"\051\034\033P \001\001 \007 \032\001\032\033%\033\031,\001*\031#"\035\031\030\001"\037\031\001\032\051-\034\001\035\031%\032"\037\001 \032\001\033\034%\033\001 \031\032/ \033\031\001\035\031/\031%\033\031,\001\031##"\035\033\032 \030 \001 /\035"\035\031\032\032\001\034%\032\001/\035"!\031\037\001\032\033\051**"\035\037$\024\001\032$ \001 \033"%\035,\032\001\033\034\031\001H\051\032\033 # -%\033 "\037\001"#\001 -$% +\032\001\033\034%\033\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\001%\035\031\001\033\034\031\001\035\031\032\051$\033\001"#\001\051\037 # \031,\030\001,\024\032#\051\037-\033 "\037%$\001 +\031-\034%\037 \032+\032 \026\001\001 \003\051-\034\001\032\033%\037%\033 "\037\001 \032\001+%,\031\001%$$\001\033 \034\031\001+"\035\031\001-\051\035 "\051\032\030\001 !\031\037\001\032\051--\031\032\032#\051$\001/\035"\035\031\032\032\001 \037\001 "\033\034\031\035\001# \031$,\032\001$ \031\001\033\034\031\001-"\037 \033 !\031\001\032\031\037-\031\032 \026\001\001 \001 \001 \017\031\037\033\035%$\001\033"\001\033\034 \032\001 \032\032\051\031\030\001\006\001"\051$,\001%\035\051\031\030\001 \032\001\033\034\031\001\051\037,\031\035\032\033%\037, \037\001"#\001\033\034\031\001*\035% \037\001\033\034%\033\001 \032\001 +/$ \031,\001 \037\001\033\034\031\001\013\003\011\026\001\001\005\034\031\001,\031# \037 \033 "\037\001 "# \001 +\031\037\033%$\001, \032"\035,\031\035\032\001\035\031#\031\035\032\001\033"\001\033\034\031\001,\024\032#\051\037-\033 "\037\001%+" \037\001 +\031-\034%\037 \032+\032\001\033\034%\033\001\051\037,\031\035$ \031\001+\031\037\033%$\001#\051\037-\033 "\037\026\001\001\004"\033\001"\037$\024\001%\035\031\001\037"\037 < \031\032\032\031\037\033 %$ \032\033\001\031;/$%\037%\033 "\037\032\001#"\035\001 \032\051-\034\001-"\037, \033 "\037\032\001/\035\031-$\051,\031,\030\001*\051\033\001 \033\001%$\032"\001 +/$ \031\032\001\033\034%\033\001\033\034\031\001*\035% \037\001 \032\001\033"\001*\031\001\051\037,\031\035\032\033"",\001%\032\001%\001 -"+/"\032 \033 "\037\001"#\001+\031-\034%\037 \032+\032\026\001\001\005\034 \032\001! \031\001 \032\001#\051\035\033\034\031\035\001\032\051//"\035\033\031,\001*\024\001\033\034\031\001\035%\037\031\001"#\001 "\037\033\031+/"\035%\035\024\001\033\034\031"\035 \031\032\001"##\031\035\031,\001%$"\037\001 \033\034\001,\031-%,\031\032\001"#\001\032\031\037\033 # -\001\031;/\031\035 +\031\037\033%\033 "\037\001\034 -\034\001 # \035+$\024\001\032\031%\033\001\033\034\031\032\031\001/%\033\034"$" \031\032\001 \037\001\033\034\031\001*\035% \037\026\001\001\005\034\031\001/\035"*$\031+\030\001\034"\031!\031\035\030\001 \032\001\033\034%\033\001"*\032\031\035!\031,\001 "/\031\035%\033 "\037\032\001 \037\001*\035% \037\032\001,"\001\037"\033\001\032\031\031+\001\033"\001$\031\037,\001\033\034\031+\032\031$!\031\032\001%\032\001\035\031%, $\024\001\033"\001+\031-\034%\037 \032\033 -\001\031;/$%\037%\033 \037\001 \037\001\033\034\031\001\032%+\031\001+%\037\037\031\035\001%\032\001"\033\034\031\035\001"\035%\037\032\030\001$ \031\001\034\031%\035\033\032\030\001$\051\037\032\030\001%\037,\001$ !\031\035\032\026 \001\001 \006\001%\035\051\031\001\033\034%\033\001 \033\001 \032\001\033\034 \032\001 +\031-\034%\037 \032\033 -\001\051\037,\031\035\032\033%\037, \037\001"#\001\033\034\031\001*\035% \037\001\033\034%\033\001-"+/"\051\037,\032\001\033\034\031\001/\035\031! "\051\032$\024\001+\031\037\033 "\037\031,\001 -\034%$$\031\037\031\032\001\033"\001\051\037,\031\035\032\033%\037, \037\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\026 \001

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\010\015 \002 \002 \031;/$%\037%\033 "\037\026\001\001 \006\033\001 \032\001\037"\033\001\033\034%\033\001\031\032\032\031\037\033 %$ \032\033\001"\035\001+\031-\034%\037 \032\033 -\001\031;/$%\037%\033 "\037\032\001%\035\031\001\035"\037\001 \037\001\033\034\031\032\031\001 -%\032\031\032\030\001*\051\033\001\032 +/$\024\001\033\034%\033\001\033\034\031\024\001\034%!\031\001/\035"!\031\037\001$ + \033\031,\001 \037\001\033\034\031 \035\001-%/%\033\024\001\033"\001\031;/$% \037\001\031\035\033% \037\001 /\034\031\037"+\031\037%\001\034\031\035\031\001 !\031\035\032 \033\024 \001 \032\001/\035\031\032\031\037\033 \026\001\001 \006\037\001 \031-"$"\024 \030\001 #"\035\001 \037\032\033%\037-\031\030\001 /"/ \051$%\033 "\037\001+",\031$\032\001 -%\037\001 *\031 \001 "##\031\035\031,\001 \033"\001%--"\051\037\033\001#"\035\001\033\034\031\001, !\031\035\032 \033\024\001\033\034 %\033 \001 \032\001 "#\033\031\037\001 "*\032\031\035!\031,\001 %-\035"\032\032 \001 \034 \034$\024\001%,%/\033 !\031\001 \032\024\032\033\031+\032\026\001\001 \003\051-\034\001%\037\001%//\035"%-\034\001+%\024\001/\035"!\031\001*\031\037\031# %$ \001 #"\035\001\051\037,\031\035\032\033%\037, \037\001\033\034\031\001*\035% \037 \026 \001 \050\012\036\005\002 \013\014\014\015\002\003\011\016\017\011\014\003\012\050\017\003\015\004\002\016\003\011/\015 \012 \001 \006\033\001 \032\001# "\035\001\033\034 \032\001%\037,\001\033\034\031\001\035\031%\032"\037\032 \001 +\031\037\033 "\037\031,\001 \037\001\033\034\031\001/\035\031! 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\010\004 \002 \002 \001 \005"\001*\031 \037\030\001 \033\034\031\001/"/\051$%\033 "\037\001 \032\001\032\031\033\001 %\032\001\033\034\031\001%//\035"; +%\033\031\001''\001 \033\035 $$ "\037\001 \032\024\037%/\033 -\001 -"\037\037\031-\033 "\037\032 \001 \033\034%\033\001 %\035\031\001#"\051\037,\001 \037 \001 %\037\001%!\031\035%\031\001\034\051+%\037\001*\035% \037\026\001\001\003 + $%\035\001\033"\001/"/\051$%\033 "\037\032\001"#\001\032/\031\031\032\030\001 \033\034\031\001\032\033\035\031\037\033\034\001"#\001\037\031\051\035%$\001-" \037\037\031-\033 "\037\032 \001 %\035\031\001\032\051*H\031-\033\001\033"\001+\031+*\031\035\001\035\031/$%-\031+\031\037\033\026\001\001\007\032\001 \033\034\031\001\032\033\035\031\037\033\034\001"#\001 -\031\035\033% \037\001-"\037\037\031-\033 "\037\032 \001 \031%\031\037 \030\001\033\034\031\024\001%\035\031\001\035\031/$%-\031,\001*\024 \001 \033\034\031\001\032 \037%$\001\032\033\035\031\037\033\034 \001 #"\051\037,\001 \037\001 \037\031\001, \032\033 \037-\033\001 -"\037\037\031-\033 "\037\032 \026\001\001\007\032\001\033\034\031\032\031\001 E +\031+*\031\035\032 F \001 %\035\031\001\035\031/$%-\031,\030\001 %\001, \032\033\035 *\051\033 "\037 \001 "#\001/"\032\032 *$\031\001 #\031%\033\051\035\031\032 \001 -%\037\001*\031\001 \031;/\031-\033\031, \001 % -\035"\032\032\001\033\034\031\001/"/\051$%\033 "\037\001%\032\001 \032 \001 %\037\033 /%\033\031,\001*\024\001\033\034\031\001\037"\035+\001"#\001\035\031%-\033 "\037\026\001\001\003 \037%$\032\001%\037,\001 -"\037\037\031-\033 "\037\032\001*\031\033\031\031\037\001\037\031\051\035"\037\032\001-\034%\037\031\001"\035\001\032\033\035\031\037\033\034\031\037\001%-\035"\032\032\001\033\034\031\001$ #\031\033 +\031\001"#\001\033\034\031\001/"/\051$%\033 "\037\001 %\037, \030 \001 H\051\032\033\001%\032\001 \033\034\001\032/\031\031\032\030\001%\035\031\001\032\051*H\031-\033\001\033"\001\031\037\031\033 -\001%\037,\001\031\037! 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\010\005 \002 \002 \035\031,\051-\031 \001 \037\034 \033 "\037\001"#\001\033%\035\031\033\031,\001/"\032\033 < \032\024\037%/\033 -\001-\031$$ \032\026\001\001\015!\031\035\001\033\034\031\001-"\051\035\032\031\001"#\001+ $$ \032\031-"\037,\032\001\033"\001 +"\037\033\034\032\030\001\033\034\031\001\032 \037%$\032\001*\031\033\031\031\037\001 \037 \033 %$\001\037\031\051\035"\037\032\001\031%\031\037\001%\032\001-"\037\037\031-\033 "\037\032\001\033"\001\033\034\031\001\033 %\035\031\033\001\037\031\051\035"\037\032\001 \032\033\035\031\037\033\034\031\037 \026 \001\001 \007\033\001\033\034 \032\001/" \037\033\030\001%-\033 \033\024\001 \037\001 /\035\031 < \032\024\037%/\033 -\001-\031$$\032\001,\035"/ \032 \001 "##\001%\037,\001 \037\034 \033 !\031\001 \037\031\051\035"\033\035%\037\032+ \033\033\031\035\032\001%\035\031\001\035\031$\031%\032\031,\001\033"\001\032\031-\051\035\031\001\033\034\031 \001 \037\031$\024\001#"\035+\031,\001-"\037\037\031-\033 "\037\032\026\001\001\006\037\001\033\031\035+\032\001"#\001\033\034\031\001 /"/\051$%\033 "\037\001+",\031$\030\001 /$%\032\033 \033\024\001-%\037\001*\031\001,\031/ -\033\031,\001 \037\001\032\051-\034\001%\001%\024\001\033\034%\033\001\035\031!\031%$ \032 \001 +%\037\024\001 \037\032 \034\033 \032 \001 \033"\001 \034"\030\001#"\035\001 \037\032\033%\037-\031\030\001\037\031\001\032 $$\032\001*\031-"+\031\001\032\033%*$\031\001#\031%\033\051\035\031\032\001 \037\001\033\034\031\001\037\031\051\035%$\001/"/\051$%\033 "\037\026\001\001 \001 \001 \025"\035\001\033\034\031\001/\051\035/"\032\031 \032 \001 "#\001\033\034 \032\001\031;%+/$\031\030\001\006\001 $$\001 ,\031\032-\035 *\031\001\033\034\031\001/\035"-\031\032\032\001*\024\001\034 -\034\001%\001/ %\037"\001 /$%\024\031\035\001$\031%\035\037\032\001%\001\037\031\001\032"\037\030\001\034 -\034\001 \037\033\031\035\031\032\033 \037$\024\001\031\037"\051\034 \030\001-%\037\001*\031\001"*\032\031\035!\031,\001\033\034\035"\051\034\001 +% \037\001 %#\033\031\035\001-\031\035\033% \037\001,\024\031\032\001%\035\031\001 \037H\031-\033\031,\001 \037\033"\001\037\031\051\035%$\001-\031$$\032\026\001\001 \021 "/\051$%\033 "\037\001@\001 $$\001*\031 \001 \032\031\033\001%\032\001\033\034\031\001 \037\031\051\035"$" -%$\001-"\037\037\031-\033 "\037\032\001#"\051\037,\001 \037\001\033 \034\031\001 *\035% \037\001"#\001% \001 / %\037"\001/$%\024\031\035 \026\001\001\021\035 "\035\001\033"\001$ \032\033\031\037 \037\001\033"\001\033\034\031\001 \037\031\001\032"\037\001"\035\001\032\031\031 \037\001\033\034\031\001\032\034\031\031\033\001+\051\032 -\030\001\033\034\031\001/"/\051$%\033 "\037\001\032\034"\032\001 "\037\031 \001 \032\033%*$\031\001\032\031\033\001"#\001-"\037\037\031-\033 "\037\032\001 %+"\037\001\037\031\051\035"\037\032\026\001\001\005\034\031\001/$%\024\031\035\001 \032\001 \033\034\031\037\001 \031;/"\032\031,\001\033"\001\033\034\031\001\037\031\001\032"\037\001%\037,\001/"/\051$%\033 "\037\001@\001 \032\001 "*\032\031\035!\031,\001%\033\001\033 +\031\001\032$ -\031\032\001\030\001&\030\001%\037,\001A\026\001\001\017\034%\037\031\032\001%\035 \031\001"*\032\031\035!\031,\001 \037\001\033\034\031\001\032 \037%$\001\032\033\035\031\037\033\034\001*\031\033\031\031\037\001 /\035\031! 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\010\006 \002 \002 *\051\033\001%$\032"\001\033\034\031\001-%/%\033\024\001\033"\001\032\033%* $ \031\001\037 \031$\024\001%-\000 \035\031,\001#\031%\033\051\035\031\032\026\001\001\003\031-"\037, \030\001\033\034\031\035\031\001%\035\031 \001 \031;/\031\035 \031\037\033 %$\001 #%-\033"\035\032\026\001\001\007\001\032\034"\035\033\001/"\033\031\037\033 % \033 "\037\001/\031\035 ",\001+%\024\001\035\031#$\031-\033\001\033\034%\033\001/"/\051$%\033 "\037\001@\001\034%\032\001/\035\031! 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\010\007 \002 \002 /"/\051$%\033 "\037\032\001"#\001 \037\031\051\035 %$\001 \032 \037%$ \037\001/%\033\033\031\035\037\032 \026\001\001\022%\033\034\031\035\001\033\034%\037\001*\031 \037\001-"\037-\031\035\037\031,\001 \033\034\001\033\034\031\001#\051\037-\033 "\037\001 "\035\001,\024\032#\051\037-\033 "\037\001"# \001 -"\037\032\033 \033\051\033 \037\001+\031-\034%\037 \032+\032 \030\001\033\034\031\001/"/\051$%\033 "\037\001%//\035"%-\034\001\033%\031\032\001, !\031\035\032 \033\024\001%\032\001\033\034\031\001 \037"\035+\001%\037,\001\032\031\031\032\001\033"\001%--" \051\037\033\001#"\035\001\033\034\031\001\031+\031\035\031\037-\031\001"#\001\032\033%* $ \033\024\001 \037\001\033\034\031\001 \037\031\051\035%$\001 /"/\051$%\033 "\037\026\001\001\027 \033\034\001 \035\031%\035,\001 \033"\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\030\001\033\034\031\001/"/\051$%\033 "\037 \032\033\001 $$\001 \033\035\031%\033 \001 \033\034\031\001 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\010\010 \002 \002 "$\031\037-\031\001 \026\031\026 \030 \001 \035%/\031\001"\035\001%\032\032%\051$\033:P\001\001\017\031\035\033% \037\001/%\033\034"\031\037\032\001\032\051-\034\001%\032\001\037\031\051\035"\032\024/\034 $ \032\001-%\037\001 -"\037\033\035 *\051\033\031\001\033"\001 \033\034\031\001\031+ \031\035\031\037-\031\001"# \001 \012\030\001#"\035\001 \037\032\033%\037-\031\026\001\001\027%\032\001\021"/\001\003\001\031;/"\032\031,\001\033"\001%\037\024\001\031\037! \035"\037+\031\037\033%$\001\031$\031+\031\037\033\032\001 \033\034%\033\001-"\051$,\001\031;/$% \037\001\033\034\031\001#\031%\033\051\035\031P\001\001\002\000%$$\024\030\001%\035\031\001\033\034\031\035\031\001#%-\033"\035\032\001\033\034%\033\001+%\024\001-"\037\033\035 *\051\033\031\001\033"\001\033\034\031\001 /\031\035\032 \032\033\031\037-\031\001"#\001#\031%\033\051\035\031\001\012\001\032\051-\034\001%\032\001+ \034\033\001*\031\001\033\034\031\001-%\032\031\001 \033\034\001 \037%//\035"/\035 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\010\012 \002 \002 \001 \005\034\031\001+%\037\037\031\035\001 \037\001\034 -\034\001\033\034 \032\001 \000\031\032\033 "\037\001"#\001 \037#\031\035\031\037-\031\001 %//$ \031\032\001-%\037\001*\031\001\051\037,\031\035\032\033"",\001*\024\001 $"" \037\001%\033\001*%\033\032\001%\037,\001/ \031"\037\032\026\001\001\023%\033\032\001%\037,\001/ \031"\037\032\001*"\033\034\001\034%!\031\001 \037\032\001%\037,\001\033\034\031\001-%/%\033\024\001#"\035\001 #$ \034\033\026\001\001\025"\035\001\033\034 \032\001\035\031%\032"\037\030\001"\037\031\001+ \034\033\001*\031\001\033\031+/\033\031,\001\033"\001+%\031 \001 \035\031-\033 \001 \037#\031\035\031\037-\031\032\001*\031\033\031\031\037\001%\001*%\033G\032\001 \037\001 %\037,\001%\001/ \031"\037G\032\001 \037\030\001*\051\033\001\033\034\031\035\031\001%\035\031\001%\001#\031\001 \032\032\051\031\032\001\034\031\035\031\026\001\001\025 \035\032\033\030 \001 *%\033\032\001%\035\031\001+%++%$\032\001\034 -\034\001 #"$$" \001 %\001, \032\033 \037-\033$\024\001, ##\031\035\031\037\033\001/%\033\034\001"#\001\031!"$\051\033 "\037\001\033\034%\037\001* \035,\032\026\001\001. !\031\037\001\033\034\031\001\031\037\031\033 -\001%\037,\001"\037\033"\031\037 -\001 ##\031\035\031\037-\031\032\001"#\001\033\034\031\032\031\001\033"\001-$%\032\032\031\032\001"#\001%\037 +%$\032\030\001\031\001\037"\033 -\031\001 -\031\035\033% \037\001, ##\031\035\031\037-\031\032\001 \037\001 \033\034\031\001*"\037\031\001 \032\033\035\051-\033\051\035\031\001%\037,\001"\051\033%\035,\001-"+/"\032 \033 "\037\001"#\001\031%-\034\001\032\031\033\001"#\001 \037\032 \026\001\001\036/"\037\001#\051\035\033\034\031\035\001 \037\032/\031-\033 "\037\030\001 \033\001 \032\001 \035\031!\031%$\031,\001\033\034%\033\001\031%-\034\001-\035\031%\033\051\035\031\001/\031\035#"\035+\032\001\033\034\031\001%-\033\001"#\001#$ \034\033\001 \037\001, ##\031\035\031\037\033\001%\024\032\026\001\001\010%\035\031$\024\001,\051\031\001\033"\001 \033\034\031 \032\031 \001 ##\031\035\031\037-\031\032\001 \037\001\032\033\035\051-\033\051\035\031\030\001*%\033\032\001,"\001\037"\033\001#$%/\001\033\034\031 \035\001#"\035\031$ +*\032\001\034\031\035 \031%\032\001/ \031"\037\032\001,"\026\001\001 \023\031-%\051\032\031\001"#\001\033\034\031\001, ##\031\035\031\037-\031\032\001"#\001\031\037\031\033 -\032\030\001\034 \032\033"\035 -%$\001$ \037\031%\031\032\030\001%\037,\001 \037\001\032\033\035\051-\033\051\035\031\001%\037,\001\051\032%\031\001 \033\001 "\051$,\001*\031\001 ## -\051$\033 \001 \033"\001 \031;/$% \037 \001 #%-\033\032\001%*"\051\033\001*%\033\001 \037\032\001 \035\031-\033$\024\001#\035"+ \001 #%-\033\032\001%*"\051\033\001/ \031"\037\032\026 \001 \001 \001 \005\034 \032\001,"\031\032\001\037"\033\001+\031%\037\030\001\034"\031!\031\035\001\033\034%\033\001\033\034\031\035\031\001 \032\001\037"\033\034 \037\001\033"\001*\031\001 \037#\031\035\035\031,\001 %\037, \001 $\031%\035\037\031,\001#\035"+\001 \033\034\031\001\031; \032\033\031\037-\031\001"#\001\033\034\031\032\031\001\033"\001\033\024/\031\032\001"#\001 \037\032\026 \001 \001 \006\037\001#%-\033\030\001\031-"$"\024\001,\031/\031\037,\032\001"\037\001\033\034\031 \001 /"\032\032 $ \033\024 \001 "#\001 \037#\031\035\031\037-\031\001%-\035"\032\032\001, !\031\035\032\031\001/"/\051$%\033 "\037\032 \026\001\001\021"/\051$%\033 "\037\001\033\034 \037 \037\001 \037\001\033\034 \032\001\032\031\037\032\031\030\001%$$"\032\001\051\032\001\033"\001! 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\011\004 \002 \002 "\032\024\037-\035%\032 \031\032\001\033\034%\033\001\035\031\032\051$\033\001#\035"+\001\033\034\031\001/%\035\033 -\051$%\035\001,\031!\031$"/+\031\037\033%$\001/%\033\034%\024\032\001"#\001\031%-\034\001 \037, ,\051%$\001 /"/\051$%\033 "\037 \026\001\001 \006\037#\031\035\031\037-\031\032\001-%\037\001*\031\001+%,\031\030\001\034"\031!\031\035\030 \001 %*"\051\033\001 \033\034\031\001 \032\033%*$\031\001*\031\034%! "\035\032\001 *\024\001\034 -\034\001 \032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 \037\001 %\035\031\001 ,\031\037\033 # \031, \030\001\033\034\051\032 \001 \035\031+"! \037\001\033\034\031\001\037\031-\031\032\032 \033\024\001 #"\035 \001 %\001\051\037 # \031,\001 \031\032\032\031\037\033 %$ \032\033\001*%\032 \032\001#"\035\001\033\034\031\032\031\001-"\037, \033 "\037\032 \026\001\001 \011"\035\031"!\031\035\030\001\031\001\032\031\031\001\033\034\035"\051\034\001/"/\051$%\033 "\037\001\033\034 \037 \037\001\033\034%\033\001 \033\001 \032\001/"\032\032 *$\031\001\033"\001\031\037\031\035%\033\031\001-$%\032\032 # -%\033"\035\024\001 \037,\032\001 \037\001\033\034\031\001%*\032\031\037-\031\001"#\001\033\034 \032\001\031\032\032\031\037\033 %$ \032\033\001*%\032 \032\026\001\001\006\037\001 \033\034 \032\001$ \034 \033\030\001\033\034\031\001/\034\031\037"+\031\037%\001"#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\001-"\051$,\001\033\034\031\037\001*\031\001,\031# \037\031,\001, \035\031-\033$\024\001 *\024\001\033\034\031 \035\001%\032\032"%\033\031,\001\032\024+/\033"+\032\026\001\001\005\034 \032\001"\051$,\001 /\035"! ,\031 \001 %\001#"\051\037,%\033 "\037\001"\037\001\034 -\034\001\033\034\031\001 /"/\051$%\033 "\037 \032\033\001\032\033\035%\033\031\024\001-"\051$,\001*\031\001%//$ \031,\001\033"\001+\031+*\031\035\032\001"#\001\033\034\031\001$%\035\031\035\001\034\051+%\037\001/"/\051$%\033 "\037\026\001\001 \006#\001\033\034\031\001 %//$ -%\033 "\037\001"#\001\033\034\031\001 / "/\051$%\033 "\037 \032\033\001\032\033\035%\033\031\024\001/\035"!\031\032\001+"\035\031 \001 /%\035\032 +"\037 "\051\032\001 \037\001%--"\051\037\033 \037\001#"\035\001 \033\034\031 \032\031 \001 /\034\031\037"+\031\037%\001%\033\001\033\034\031\001\034\051+%\037\001$\031!\031$ \030\001\033\034\031\037\001\031\001 \034%!\031\001\035\031%\032"\037\001\033"\001\000\031\032\033 "\037\001\034\031\033\034\031\035 \001 \033\034\031\001\033\024/\031\032\001 "#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\030\001%\032\001-%\033\031"\035 \031,\001*\024\001\033\034\031\001\013\003\011\030\001 -%\037\001*\031\001\032% ,\001\033" \001 \031; \032\033\001%\032\001 \031\032\032\031\037\033 %$ \032\033\001 \037,\032\026 \001 \006#\001\033\034\031\001%*"!\031\001 \032 \001 %--\031/\033\031,\001%\032\001 \031!\031\037\001\035\031%\032"\037%*$\031 \030\001\033\034\031\037\001 \033\001-%\037\001*\031\001\032% ,\001\033\034%\033\001 % *\032"$\051\033\031\001 -"\037# ,\031\037-\031\001 \037\001\033\034\031\001 \031\001 "#\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\001 %\032\001\031\032\032\031\037\033 %$ \032\033\001 \037,\032\001 \034%\032\001*\031\031\037 \001 \051\037,\031\035+ \037\031, \026\001\001\013 "\051*\033\001"\051$,\001 \033\034\031\037\001 *\031\001-%\032\033\001"\037\001\033\034 \032\001$"*%$\001%\032\032\051+/\033 "\037\001"#\001\031\032\032\031\037\033 %$ \032+\001% \032\001 \033\001 /\031\035\033% \037\032\001\033"\001\033\034\031\001-%\033\031"\035 %\033 "\037\001"#\001+\031\037\033%$\001-"\037, \033 "\037\032\001 \037\001\031\037\031\035%$\026\001\001 \005 \034 \032\001 \032\001\037"\033\001\033"\001\032%\024\001\033\034%\033\001\033\034\031\001 \013\003\011\001+\051\032\033 \001 *\031\001, \032-%\035,\031,\030\001\034"\031!\031\035\030\001 "\035\001\033\034%\033\001\031\032\032\031\037\033 %$ \032\033\001\031;/$%\037%\033 "\037\032\001,"\001 \037"\033\001%\033\033% \037\001#"\035\001\032"+\031\001 -"\037, \033 "\037\032\026\001\001\006\033\001 \032\001 +\031\035\031$\024\001 \033"\001\032%\024\001 \033\034%\033\001 \033\001"\051$,\001\037"\001$"\037\031\035\001*\031\001/"\032\032 *$\031\001 #"\035\001\033\034\031\001\013\003\011\001 \033"\001 \051\037 !\031\035\032%$$\024\001%\032\032\051+\031\001\031\032\032\031\037\033 %$ \032\033\001-$% +\032\001"#\001/%\033\034"$"\024\026\001\001 \007\032\001\032\051-\034\030\001#\051\035\033\034\031\035\001\031\037%\031+\031\037\033\001 \033\034\001 \033\034\031\001\013\003\011\001"\051\034\033\001\033"\001#"$$"\001 # \035\032\033\001#\035"+ \001 \031+/ \035 -%$\001H\051\032\033 # -%\033 "\037\001#"\035\001\031%-\034\001-%\033\031"\035\024\001"#\001/%\033\034"$"\024 \001 \033\034%\033\001 \033\001\032\031\031\032\001\033"\001,\031\032-\035 *\031 \026

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\011\005 \002 \002 \006 \015\001\016\004\011\005\007\024 \017 \007 \007 \003\021\022\022\001\005\023\007\001\014\020\007 \006\012\014\006\010\021\003\017\012\014 \007 \001 \005 \034\031\001/\035 +%\035\024\001/\051\035/"\032\031\001"#\001\033\034 \032 \001 \033\034\031\032 \032\001%\032\001\033"\001-%\032\033\001,"\051*\033\001"\037\001\033\034\031\001$"*%$\001%\032\032\051+/\033 "\037\001"#\001 \031\032\032\031\037\033 %$ \032+\001 \033\034\001\035\031%\035,\001\033"\001/%\033\034"$" -%$\001-%\033\031"\035 \031\032\001 \037\001\033\034\031\001\013\003\011\026\001\001\005"\001,"\001\033\034 \032\030\001 \033\001%\032\001# \035\032\033\001 \037\031-\031\032\032%\035\024\001\033"\001\051\037,\031\035+ \037\031\001\033\034\031\001 \051\037 !\031\035\032%$ \033\024\001-$% +\001"# \001 +\031\037\033%$\001-"\037, \033 "\037\001%\032\001\031\032\032\031\037\033 %$ \032\033\001 \037, \032 \026\001\001\006\001 -\034"\032\031\001\033"\001#"-\051\032\001"\037 \001 \033\034\031\001\033"\001\031;%+/$\031\032\030 \001 \032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\026\001\001\005\034\031\001\032\033\035\051-\033\051\035\031\001"#\001\033\034\031\001 %\035\051+\031\037\033\001%\032\001-"\037\032\033\035\051-\033\031,\001 \037\001 \033\034\031\001#"$$" \037\001#"\051\035\001/%\035\033\032\014 \001\001 \025 \035\032\033\030\001%\001\033\034\031"\035\031\033 %$\001/\035\031\032\031\037\033%\033 "\037\001"#\001 \031\032\032\031\037\033 %$ \032+K \001 \032 \031"\037,\030\001%\001-\035 \033 \000\031\001"#\001\031\032\032\031\037\033 %$ \032+K \001 \033 \034 \035,\030\001\033\034\031\001/\035\031\032\031\037\033%\033 "\037\001"#\001%\001! %*$ \031\001\037"\037 < \031\032\032\031\037\033 %$ \032\033\001%$\033\031\035\037%\033 !\031K \001 \007\037,\001#"\051\035 \033\034 \030\001\033\034\031\001 %//$ -%\033 "\037\001"#\001\033\034\031\001/"/\051$%\033 "\037 \032\033\001! \031\001#"\035\001 *\035% \037 \032\001 \033\034\001\035\031%\035,\001\033"\001\032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037 \026 \001 \001 \005\034\031\001%\035\051+\031\037\033\001*\031%\037\001 \033\034\001%\001,\031!\031$"/+\031\037\033\001"#\001\033\034\031\001\031\032\032\031\037\033 %$ \032\033\001\031;/$%\037%\033"\035\024\001\032\033\035%\033\031\024\001 \034 -\034\001 \032\001\051\032\031,\001\033"\001 \037, ,\051%\033\031 \001 -%\033\031"\035 \031\032\001*\024\001\037\031-\031\032\032%\035\024\001%\037,\001\032\051## \031\037\033\001-"\037, \033 "\037\032\026\001\001\003\051-\034\001 -"\037, \033 "\037\032\001%\035\031\001 \033\035\031%\033\031,\001%\032\001 \033\034\031\001\051\037,\031\035$\024 \037\001+\031-\034%\037 \032+\032\001\033\034%\033\001-%\051\032\031\001"*\032\031\035!\031,\001\032 + $%\035 \033 \031\032\001"#\001 -%\033\031"\035\024\001+\031+*\031\035\032\026\001\001C%\035 %\037-\031\001 \032\001\033\034\051\032\001%--"\051\037\033\031,\001#"\035\001 %\032\001\033\034\031\001\035\031\032\051$\033\001"# \001 \037\033\031\035#\031\035\031\037-\031\001"\035\001 +%$#\051\037-\033 "\037\001"#\001\033\034\031\001 -%\051\032%$\001+\031-\034%\037 \032+\032\026\001\001\007\001,\031\032-\035 /\033 "\037\001%\032\001\033\034\031\037\001/\035"! 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\011\006 \002 \002 \033\035\031%\033+\031\037\033\032\026\001\001\005\034\031\032\031\001\035\031\032\051$\033\032\001%$"\037\031 \030\001\034"\031!\031\035\030 \001 \031\035\031\001\037 "\033\001\032\051## \031\037\033\001\033"\001/\035"!\031\001\031\032\032\031\037\033 %$ \032+\001 \037\001\033\034\031\001 \013\003\011\001\035"\037\026\001\001 \027 \031\001\031\035\031\001 \033\034\031\037\001 $\031#\033\001 \033\034\001"\037\031\001"#\001\033\034\035\031\031\001/"\032\032 $ \033 \031\032\026\001\015\037\031\030\001\033\034\031\001-"\035\035\031-\033\001 \031\032\032\031\037\033 %$ \032\033\001+\031-\034%\037 \032+\032\001#"\035\001\032-\034 "/\034\035\031\037 %\001"\035\001,\031/\035\031 \032\032 "\037\001\034%!\031\001\024\031\033\001\033"\001*\031\001 ,\031\037\033 # \031,\030\001 \035\031\000 \035 \037\001 #\051\035\033\034\031\035\001 \037!\031\032\033 %\033 "\037 \026\001\001\005"\030\001\033\034\031\001%\037"+%$ \031\032\001%\035\031\001\033\034\031\001\035\031\032\051$\033\001"#\001-"\037#$%\033 \037\001+\051$\033 /$\031\001 $$\037\031\032\032\031\032\001 \033\034%\033\001 \031%-\034\001 %\035 \032\031\032\001%\032\001%\001\035\031\032\051$\033\001"#\001\033\034\031 \035\001"\037\001\031\032\032\031\037\033 %$ \032\033\001+\031-\034%\037 \032+\032\026\001\001\015\035\001\033\034\035\031\031\030\001\033\034%\033\001 \032-\034 "/\034\035\031\037 %\001%\037,\001,\031/\035\031\032\032 "\037\001%\032\001\033\034 \031\024\001%\035\031\001,\031\032-\035 *\031,\001 \037\001\033\034\031\001\013\003\011\001,"\001\037"\033 \001 \031; \032\033\026 \001 \001 \005\034\031"\035\031\033 -%$\001%\037,\001/\035%-\033 -%$\001-\034%$$\031\037\031\032\001\033\034%\033\001\033\034\031 \001 \031\032\032\031\037\033 %$ \032\033\001%//\035"%-\034\001\034%\032\001/"\032\031,\001\033"\001 -%\033\031"\035 %\033 "\037\001 \037\001"\033\034\031\035\001# \031$,\032\001 \031\035\031 \001 \033\034\031\037\001/\035\031\032\031\037\033\031,\026\001\001\027\034%\033\001%\032\001\035\031!\031%$\031,\001\033\034\035"\051\034\001\033\034 \032 \001 -\035 \033 \000\031\001 \032\001\033\034%\033\001 \033\034\001\035\031%\035,\001\033"\001-\031\035\033% \037\001/\034\031\037"+\031\037%\030 \001 \031\032\032\031\037\033 %$ \032+ \001 /\035\031\032\031\037\033\032 \001 %\001$ + \033\031,\001-%/%\033\024\001 \037 \001 %--"\051\037\033 \037\001#"\035\001!%\035 %\037-\031 \026\001\001\007\001\037"\037 < \031\032\032\031\037\033 %$ \032\033\001%$\033\031\035\037%\033 !\031\001%\032\001\033\034\031\037\001"##\031\035\031,\001\033\034\035"\051\034\001\033\034\031\001 \031;/$%\037%\033"\035\024\001\032\033\035%\033\031\024\001"#\001/"/\051$%\033 "\037\001\033\034 \037 \037\026\001\001 \005\034 \032\001 \032\001%\001\032\033\035%\033\031\024\001\033\034%\033\001,\031\032-\035 *\031\032 \001 %\001 \032\033\035 *\051\033 "\037\001"#\001, !\031\035\032\031\001 #\031%\033\051\035\031\032\001"\035\001/\034\031\037"+\031\037% \001 %\032\001 \033\001-%\037\001*\031\001\031;/\031-\033\031,\001%-\035"\032\032\001%\001/"/\051$%\033 "\037\026\001\001 \022%\033\034\031\035\001\033\034%\037\001\032\031\031 \037\001\033\034\031\001\032 + $%\035 \033 \031\032\001\032\034 %\035\031,\001*\024\001 \037, ,\051%$\001+\031+*\031\035\032\030\001!%\035 %\037-\031\001 \032 \001 \033%\031\037\001%\032\001 \033\034\031\001\037"\035+\026\001\001\003\033%*$\031\001\032 + $%\035 \033 \031\032\001\033\034\031\037\001\035\031\000 \035\031\001\031;/$%\037%\033 "\037\001%\037,\001-%\037\001*\031\001%--"\051\037\033\031,\001#"\035\001\033\034\035"\051\034\001 \033\034\031\001 \037#$\051\031\037-\031\001"#\001!%\035 "\051\032\001/\035\031\032\032\051\035\031\032\001\031 \037 %-\033\031,\001"\037\001\033\034\031\001/"/\051$%\033 "\037\026\001\001 \011",\031$\032\001\031\035\031\001\033\034\031\037\001,\031\032-\035 *\031,\001 \034\031\035\031\001\033\034 \032\001%//\035"%-\034\001\034%\032\001 *\031\031\037 \001 \031##\031-\033 !\031$\024\001\051\033 $ \031,\030\001 \037-$\051, \037\001\033\034\031\001 # \031$,\001"#\001\031!"$\051\033 "\037%\035\024\001 "$"\024\026\001\001 \001 \001 \007\001-%\032\031\001%\032\001\033\034\031\037\001+%,\031\001#"\035\001\034"\001\033\034 \032\001%//\035"%-\034\001-"\051$,\001/\035"! 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\011\007 \002 \002 \037\031\001,\031# \037 \033 "\037\032\030\001%\001/"/\051$%\033 "\037 \032\033\001+",\031$\001%\032\001\033\034\031\037\001/\035"/"\032\031,\001#"\035\001\034"\001\032-\034 "/\034\035\031\037 %\001%\037,\001 ,\031/\035\031\032\032 "\037\001-"\051$,\001*\031\001 \037!\031\032\033 %\033\031,\001 \037\001\033\034\031\001#\051\033\051\035\031\026\001\001 \013\051\031\001\033"\001\033\034\031\001 /"\032\032 *$\031\001 \035\031%\033\031\035\001-%/%\033\024\001 \037\001 %-"\051\037\033 \037 \001 #"\035\001\033\034\031\001%\037"+%$ \031\032\001#"\051\037,\001 \037\001/\035\031! 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\011\014 \002 \002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002 B \001 \003\024+"\037\032\030\001O\026\001 &'':\026\001E\017"+/\051\033%\033 "\037%$\001\011",\031$\032\001"#\001\002+\031\035\031\037\033\001\021\035"/\031\035\033 \031\032\026F\001 \023\011\002\006\014\012\016\002\006\012 \001 \023\016\010\022\011\002\015\014\035 \001 \050:\026\001 \050 \001 D \001 \004 -\034"$\032"\037\030\001\013\026\001&'':\026\001E\023 "$" -%$\001\007\033"+ \032+\001%\037,\001\017\031$$\001\005\034\031"\035\024\026F\001 \024\003\007\006\011\015\014\012\005\027\012*\011\014\003\005\004\026\012\016\002\006\012 \012 #\022\011\017\005\014\005\031\022\026\012\005\027\012-\011\005\017\005\025\011\010\016\017\012\016\002\006\012-\011\005\020\015\006\011\010\016\017\012\024\010\011\015\002\010\015\014\035 \001 \050A:\026\001 &'B \001 \001 \012\024+%\037\030\001\003\026\001&'': \026\001E\005\034\031\001\013 %\037"\032 \032\001"#\001\011\031\037\033%$\001\013 \032"\035,\031\035\032\014\001\005\034\031\001\021\035"*$\031+\001"#\001\022\031 # -%\033 "\037\026F\001\001 \001 \050\002\002\007\016\017\012 !\015/\011\015\037\012\005\027\012\017\011\002\011\010\016\017\012#\014\026\010\022\005\017\005\025\026\035\012 D\026\001 DA \001 \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001&A> \001 > \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 \050> \001 \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 B \001 \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 B> \001 & \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001&B& \001 A \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001&D' \001 \050 \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 \001 B \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026 \001 &DD \001 \001

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\012\015 \002 \002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002 D \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001&D \001 \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 \001 \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001&\050 \001 > \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001&\050 \001 &' \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001&\050B \001 & \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 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\050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 D \001

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\012\004 \002 \002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002 B \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026\001 &'':\026\001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 D \001 D \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 \001 \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 D \001 \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 \001 > \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 > \001 \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 > \001 \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 A \001 & \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026 \001 \001 A \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026 \001 &'':\026 \001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 & \001 \050 \001 \005%\037,"\037\030\001\022\026\001\031\033\001%$\026\001 &'':\026\001 E\003-\034 "/\034\035\031\037 %\030\001EO\051\032\033\001\033\034\031\001\025%-\033\032\014F\001\027\034%\033\001\027\031\001\016\037"\001\006\037\001& ''\026F\001 \001 \024\010\022\011%\005\031\022\004\015\002\011\016\012!\015\014\015\016\004\010\022 \026\001'' < A:\026\001 > \001 B \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 B\050 \001 \001

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\012\005 \002 \002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002 D \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 BD \001 \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 A'A \001 \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 \001 > \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 B \001 &' \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 B \001 & \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 A \001 && \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 B> \001 &A \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 D \001 &\050 \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 D \001 &B \001 \003\034"\035\033\031\035\030\001\002\026\001>>:\026 \001 \050\012\022\011\014\003\005\004\026\012\005\027\012\031\014\026\010\022\011\016\003\004\026\000\027\004\005\020\012\003\022\015\012\015\004\016\012\005\027\012\003\022\015\012\016\014\026\017\007\020\012\003\005\012\003\022\015\012\016\025\015\012\005\027\012#\004\005%\016\010 \026\001 \001 \004\031\001?"\035\014\001\027 $\031\024 \026\001A'B \001 &D \001 \027\034 \033%\031\035\030\001\022\026\001&'B:\026 \001 \050\002\016\003\005\020\026\012\005\027\012\016\002\012\015\031\011\006\015\020\011\010\000\020\016\025\011\010\012\032\007\017\017\015\003\014+\012\031\014\026\010\022\011\016\003\004\011\010\012\006\004\007\025\014+\012\016\002\006\012\003\022\015\012 \001 \016\014\003\005\002\011\014\022\011\002\025\012\004\011\014\015\012\005\027\012\020\015\002\003\016\017\012\011\017\017\002\015\014\014\012\011\002\012\050\020\015\004\011\010\016 \026\001\004\031\001?"\035\014\001\023\035"%,%\024\001\023""\032\026 \001 DB \001 \001

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\012\007 \002 \002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002 B \001 \012\051$$\030\001\013\026\010\026\001>DB:\026\001E\005\034\031\001\002##\031-\033\001"#\001\002\032\032\031\037\033 %$ \032+\001"\037\001\005%;"\037"+\024\001 R \001 \005"\001\005\034"\051\032%\037,\001?\031%\035\032\001"#\001 \001 \003\033%\032 \032\026F\001 \021\022\015\012-\004\011\003\011\014\022\012\005\007\004\002\016\017\012\027\005\004\012\003\022\015\012#\022\011\017\005\014\005\031\022\026\012\005\027\012\024\010\011\015\002\010\015 \035\012 B D':\026\001 AD \001 D \001 \012\051$$\030\001\013\026\010\026\001>DB:\026\001E\005\034\031\001\002##\031-\033\001"#\001\002\032\032\031\037\033 %$ \032+\001"\037\001\005%;"\037"+\024\001 R \001 \005"\001\005\034"\051\032%\037,\001?\031%\035\032\001"#\001 \001 \003\033%\032 \032\026F\001 \021\022\015\012-\004\011\003\011\014\022\012\005\007\004\002\016\017\012\027\005\004\012\003\022\015\012#\022\011\017\005\014\005\031\022\026\012\005\027\012\024\010\011\015\002\010\015 \035\012 BD':\026\001 A \001 \001 \012\051$$\030\001\013\026\010\026\001>DB:\026\001E\005\034\031\001\002##\031-\033\001"#\001\002\032\032\031\037\033 %$ \032+\001"\037\001\005%;"\037"+\024\001 R \001 \005"\001\005\034"\051\032%\037,\001?\031%\035\032\001"#\001 \001 \003 \033%\032 \032\026F\001 \021\022\015\012-\004\011\003\011\014\022\012\005\007\004\002\016\017\012\027\005\004\012\003\022\015\012#\022\011\017\005\014\005\031\022\026\012\005\027\012\024\010\011\015\002\010\015 \035\012 BD':\026\001 A&' \001 \001 \012\051$$\030\001\013\026\010\026\001>DB:\026\001E\005\034\031\001\002##\031-\033\001"#\001\002\032\032\031\037\033 %$ \032+\001"\037\001\005%;"\037"+\024\001 R \001 \005"\001\005\034"\051\032%\037,\001?\031%\035\032\001"#\001 \001 \003\033%\032 \032\026F\001 \021\022\015\012-\004\011\003\011\014\022\012\005\007\004\002\016\017\012\027\005\004\012\003\022\015\012#\022\011\017\005\014\005\031\022\026\012\005\027\012\024\010\011\015\002\010\015 \035\012 BD':\026\001 A&& \001 > \001 \012\051$$\030\001\013\026\010\026\001>DB:\026\001E\005\034\031\001\002## \031-\033\001"#\001\002\032\032\031\037\033 %$ \032+\001"\037\001\005%;"\037"+\024\001 R \001 \005"\001\005\034"\051\032%\037,\001?\031%\035\032\001"#\001 \001 \003\033%\032 \032\026F\001 \021\022\015\012-\004\011\003\011\014\022\012\005\007\004\002\016\017\012\027\005\004\012\003\022\015\012#\022\011\017\005\014\005\031\022\026\012\005\027\012\024\010\011\015\002\010\015 \035\012 BD':\026\001 A&\050 \001 \001 \002\035\031\032\034\031#\032\024\030\001\011\026 \030\001\011%\033\033\034\031\037\030\001\011\026\001&''B:\026\001E\005%;"\037"+\024\030\001\021"$\024+"\035/\034 \032+\030\001%\037,\001\012 \032\033"\035\024\014\001\007\037\001 \001 \006\037\033\035",\051-\033 "\037\001\033"\001\021"/\051$%\033 "\037\001\005\034 \037 \037\026F\001 #\022\011\017\005\014\005\031\022 \026\012\005\027\012\024\010\011\015\002\010\015 \026\001&\026\001 \001 \001 \011%\033\033\034\031\037\030\001\011\026\001&''>:\026\001 E \017\034 -\031\037\032\030\001\002\032\030\001%\037,\001\003/\031%\033 "\037\026 F \001 \036\005 \014 \026 \001 \050A:\026\001 \001 & \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A \001 A \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A\050 \001 \050 \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 AB \001 B \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A> \001 \001 \001

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\012\010 \002 \002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002\002 \002 D \001 \003"*\031\035\030\001\002\026\001E\005\034\031\001\005"\001\025%-\031\032\001"#\001\025 \033\037\031\032\032\026F\001&'':\001\006\037\001\003 \037\034\030\001\022\026\001 \021\022\011\002$\011\002\025\012\050\032\005\007\003\012\013/\005\017\007\003\011\005\002\000 \001 *\011\014\003\005\004\011\010\016\017+\012#\022\011\017\005\014\005\031\022\011\010\016\017+\012\016\002\006\012#\005\017\011\003\011\010\016\017\012#\015\004\014\031\015\010\003\011/\015\014\012 //\026\001A'> < A&':\001\017%+*\035 ,\031\014\001 \017%+*\035 ,\031\001\036\037 !\031\035\032 \033\024\001\021\035\031\032\032 \026\001 A'> \001 \001 \003"*\031\035\030\001\002\026\001E\005\034\031\001\005"\001\025%-\031\032\001"#\001\025 \033\037\031\032\032\026F\001&'':\001\006\037\001\003 \037\034\030\001\022\026\001 \021\022\011\002$\011\002\025\012\050\032\005\007\003\012\013/\005\017\007\003\011\005\002\000 \001 *\011\014\003\005\004\011\010\016\017+\012#\022\011\017\005\014\005\031\022\011\010\016\017+\012\016\002\006\012#\005\017\011\003\011\010\016\017\012#\015\004\014\031\015\010\003\011/\015\014\012 //\026\001A'> < A&':\001\017%+*\035 ,\031\014\001 \017%+*\035 ,\031\001\036\037 !\031\035\032 \033\024\001\021\035\031\032\032 \001 A' \001 \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A \001 > \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A\050 \001 &' \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A \001 & \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A \001 && \001 \002\035\031\032\034\031#\032\024\030\001\011\026 \030\001\011%\033\033\034\031\037\030\001\011\026\001&''B:\026 \001 E\005%;"\037"+\024\030\001\021"$\024+"\035/\034 \032+\030\001%\037,\001\012 \032\033"\035\024\014\001\007\037\001 \001 \006\037\033\035",\051-\033 "\037\001\033"\001\021"/\051$%\033 "\037\001\005\034 \037 \037\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012\024\010\011\015\002\010\015 \026\001&\026\001 \001 &A \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026 \001 A' \001 &\050 \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026 \001 A& \001 &B \001 \003"*\031\035\030\001\002\026\001>':\026\001E\002!"$\051\033 "\037\030\001\021"/\051$%\033 "\037\001\005\034 \037 \037\030\001%\037,\001\002\032\032\031\037\033 %$ \032+\026F\001 #\022\011\017\005\014\005\031\022\026\012\005\027\012 \012 \024\010\011\015\002\010\015 \026\001 \050A :\026\001 A A \001 \001

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